Blood Cross Flow Filtration Through Artificial Membranes

  • M. Y. Jaffrin


Membrane separation is used in various stages of blood purification. The best known application is hemodialysis used for the treatment of end-stage renal failure (1, 2). In this process, uremic toxins are removed by diffusion through a semi-permeable membrane which separates the circulating blood from an ionic solution, the dialysate.


Shear Rate Hollow Fiber Concentration Polarization Membrane Area Transmembrane Pressure 
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  1. 1.
    Kolff, W.J., 1947, New ways of treating uremia, Churchill Ltd, London.Google Scholar
  2. 2.
    Frost, T.H., Ed. 1978, Technical aspects of renal dialysis. Pitman Medical.Google Scholar
  3. 3.
    Henderson, L.W., Colton, C.K. and Ford, C.A., 1975, Kinetics of hemodiafiltration. II. Clinical characterization of a new blood cleansing modality, J. Lab. Clin. Med. 85:372–380.PubMedGoogle Scholar
  4. 4.
    Man, N.K. and Funck-Brentano, J.L., 1977, L’hémofiltration. Actualités néphrologiques de l’Hôpital Necker. Flammarion Paris. 1: 387–3Google Scholar
  5. 5.
    Solomon, B.A., Castino, F., Lysaght, M.J., Colton, C.K., and Friedman, L.I., 1978, Continuous flow membrane filtration of plasma from whole blood, Trans. Am. Soc. Artif. Int. Organs 24:21–26.Google Scholar
  6. 6.
    Nose, Y., and Malchesky, P.S., 1981, Therapeutic membrane plasmapheresis, Therapeutic plasmapheresis, Ota et ed., Schattauer, Stuttgart, 3-14.Google Scholar
  7. 7.
    Gurland, H.J., Samtleben, W., and Blumenstein, M., 1983, Therapeutic membrane plasmapheresis, Present state and future aspects. Life Support Systems, 1:61–70PubMedGoogle Scholar
  8. 8.
    Agishi, T., Kaneko, I., Hasuo, Y. et al., 1980, Double filtration plasmapheresis. Trans. Am. Soc. Artif. Int. Organs, 26:406–410.Google Scholar
  9. 9.
    Lysaght, M.J., Samtleben, W., Schmidt, B., Gurland, H.J., 1984, Analytical comparison of single pass and dead-end operation in cascade filtration plasmapheresis. Artificial Organs, 8:481–488.PubMedCrossRefGoogle Scholar
  10. 10.
    Homma, Y., Mikami, Y., Tamachi, H. et al., 1986, Comparison of selectivity of LDL removal by double filtration and dextran sulfate cellulose column plasmapheresis, Atherosclerosis, 60:23–27.PubMedCrossRefGoogle Scholar
  11. 11.
    Jaffrin, M.Y., Ding, L.H., Laurent, J.M., 1992, Kinetics of concentration-polarization formation in cross flow filtration of plasma from blood: experimental results, J. Memb. Sci., 72:267–275.CrossRefGoogle Scholar
  12. 12.
    Blatt, W.F., Dravid, A., Michaels, A.S., Nilsen, L., 1970, Solute polarization and cake formation in membrane ultrafiltration: causes, consequences and control techniques, In Flinn F.E. (ed) Membrane Science and Technology, New-York, Plenum, 47:97.Google Scholar
  13. 13.
    Colton, C.K., Henderson, L.W., Ford, C.A., Lysaght, M.J., 1975, Kinetics of hemodiafiltration: I. In vitro characteristics of a hollow fiber blood ultrafilter, J. Lab. Clin. Med. 85:355–371.PubMedGoogle Scholar
  14. 14.
    Romero, C.A., Davis, R.H., 1988, Global model of cross flow microfiltration based on hydrodynamic particle diffusion, J. Memb. Sci., 39:157–185.CrossRefGoogle Scholar
  15. 15.
    Malbrancq, J.M., Jaffrin, M.Y., Bouveret, E., Anglerand, R., Vantard, G., 1984, Plasma filtration through a microporous membrane, ASAIO J., 7:16–24.Google Scholar
  16. 16.
    Gupta, B.B., Jaffrin, M.Y., Ding, L.H., Dohi, T., 1986, Membrane plasma filtration through small-area hollow fiber filters, Artificial Organs, 10:45–51.PubMedCrossRefGoogle Scholar
  17. 17.
    Raff, M., Ohmayer, M., Göhl, H., Samuelson, G., 1984, Influence of geometric parameters on filtration flux in plasmafilters, In Therapeutic Apheresis: A critical look, Ed. by Nose, Y, Malchesky, P.S., Smith, J. W., ISAO Press, Cleveland, 115–121.Google Scholar
  18. 18.
    Jaffrin, M.Y., Malbrancq, J.M., Vantard, G., Martin, T., Faure, A., 1985, Rheological aspects of plasma separation by membrane, Clinical Hemorheology, 5:231:240.Google Scholar
  19. 19.
    Zydney, A.L., Colton, C.K., 1987, Fundamental studies and design analyses for cross flow membrane plasmapheresis in artificial organs, Ed. by Andrade, J.D., et al., VCH Publishers, Florida, USA, 343–358.Google Scholar
  20. 20.
    Sueoka, A., Malchesky, P.S., Nose, Y., 1983, Effects of blood composition on membrane plasma séparation, Plasmapheresis, Ed. by Nose, Y., Malchesky, P.S., Smith, J.W., ISAO Press, Cleveland, 93–103.Google Scholar
  21. 21.
    Zydney, A.L., Colton, C.K., 1982, Continuous flow membrane plasmapheresis: theoretical models for flux and hemolysis prediction, Trans. Am. Soc. Artif. Intern. Organs, 28:408–412.PubMedGoogle Scholar
  22. 22.
    Malbrancq, J.M., Jaffrin, M.Y., Bouveret, E., Angleraud, R., Vantard, G., 1982, Factors governing plasma filtration rate in plasmapheresis by plane microporous membranes, Proc. 9th ESAO, Life Support Systems, 11:46–50.Google Scholar
  23. 23.
    Forstrom, R.J., Bartlett, K., Blackshear, P.L., Wood, T., 1975, Formed element deposition onto filtering walls, Trans. Am. Soc. Artif. Intern. Organs, 21:602–607.PubMedGoogle Scholar
  24. 24.
    Malchesky, P.S., Wojcicki, J., Moorman, M., Pentermann, E.J., Nose, Y., 1984, Blood cell effects in membrane plasma separation, Trans. Am. Soc. Artif. Intern. Organs, 30:313–317.PubMedGoogle Scholar
  25. 25.
    Vassilief, C.S., Leonard, E.F., Stepner, T.A., 1985, The mechanism of cell rejection in membrane plasmapheresis. Clinical Hemorheology, 5:7–15.Google Scholar
  26. 26.
    Cox, R.G., Mason, S.G., 1971, Suspended particles in fluid flow through tubes, Annual Review of Fluid Mechanics, 3:291–316.CrossRefGoogle Scholar
  27. 27.
    Wang, N.M.L., Keller, K.H., 1979, Solute transport induced by erythrocyte motions in shear flow, Trans. Am. Soc. Artif Intern. Organs, 25:14–17.PubMedCrossRefGoogle Scholar
  28. 28.
    Eckstein, E.C., Bailey, D.G., Shapiro, A.H., 1977, Self diffusion of particles in shear flow of a suspension, J. of Fluid Mech., 79:191–208.CrossRefGoogle Scholar
  29. 29.
    Rock, G. Titley, P., McCombie, N., 1986, Plasma collection using an automated membrane device, Transfusion, 26:269–271.PubMedCrossRefGoogle Scholar
  30. 30.
    Beaudoin, G., Jaffrin, M.Y., 1989, Plasma filtration in Couette flow membrane devices, Artificial Organs, 13:43–51.PubMedCrossRefGoogle Scholar
  31. 31.
    Ohashi, K., Tashiro, K., Kushiya, F. et al., 1988, Rotation-induced Taylor vortex enhances filtrate flux in plasma separation, Trans. Am. Soc. Artif. Intern. Organs, 34:300–307.Google Scholar
  32. 32.
    Vigo, F., Uliana, C., Lupino, P., 1985, The performance of a rotating module in oily emulsions ultrafiltration, Separation Sci. and Technology, 20:213–230.CrossRefGoogle Scholar
  33. 33.
    Kroner, H.K., Nissinen, V., 1988, Dynamic filtration of microbial suspensions using an axially rotating filter, J. of Memb. Sci., 36:85–100.CrossRefGoogle Scholar
  34. 34.
    Taylor, G.I., 1936, Fluid friction between rotating cylinders, 1. Torque measurements, Proc. Royal. Soc., 157:546–564.CrossRefGoogle Scholar
  35. 35.
    Jaffrin, M.Y., Beaudoin, G., Ding, L.H., Djennaoui, N., 1989, Effect of membrane characteristics on the performance of Couette rotating plasma separation devices, Proc. Am. Soc. Artif Intern. Organs, 35:690–693.CrossRefGoogle Scholar
  36. 36.
    Schlichting, H., 1968, Boundary layer theory, Mac Graw Hill, New-York.Google Scholar
  37. 37.
    Zydney, A.L., Saltzman, W.M., Colton, C.K., 1989, Hydraulic resistance of red cell beds in an unstirred filtration cell, Chem. Eng. Sci., 44:147–155.CrossRefGoogle Scholar
  38. 38.
    Galletti, P.M., Richardson, P.D., Trudeil, L.A., 1983, Oscillating blood flow enhances membrane plasmapheresis, Trans. Am. Soc. Artif. Intern. Organs, 23:279–282.Google Scholar
  39. 39.
    Jaffrin, M.Y., Gupta, B.B., Cannon, R.I., Ding, L.H., 1984, Enhancement of plasma filtration in hollow fiber filters by pulsatile blood flow. Proc. XI ESAO, Life Support Systems, Vol. 2, Suppl. 1:207–210.Google Scholar
  40. 40.
    Gupta, B.B., Ding, L.H., Jaffrin, M.Y., 1985, High efficiency small membrane area plasmapheresis using pulsatile blood flow, Progress in artificial organs, Ed. by Nose Y., ISAO Press. 891:895.Google Scholar
  41. 41.
    Jaffrin, M.Y., Ding, L.H., Gupta, B.B., 1987, Rationale of filtration enhancement in membrane plasmapheresis by pulsatile blood flow. Life Support Systems, 5:261–271.Google Scholar
  42. 42.
    Schooneman, F., Stoltz, J.F., Streif, F. et al., 1986, Technical study and biological results obtained with a pulsatile flow plasmapheresis system, Life Support Systems, 4:362–365.Google Scholar
  43. 43.
    Ding, L.H., Laurent, J.M., Jaffrin, M.Y., 1991, Dynamic filtration of blood: a new concept for enhancing plasma filtration, The Int. J. of Artif. Organs, 14:365–370.Google Scholar
  44. 44.
    Bellhouse, B.J., Lewis, W.H., 1988, A high efficiency membrane separator for donor plasmapheresis, Trans. Am. Soc. Artif. Intern. Organs, 34:747–754.Google Scholar
  45. 45.
    Bellhouse, B.J., Bellhouse, F.N., Curl, C.M. et al., 1973, A high efficiency membrane oxygenator and pulsatile pumping system and its application to animal trials, Trans. Am. Soc. Artif. Intern. Organs, 19:72–79.PubMedCrossRefGoogle Scholar
  46. 46.
    Solomon, B.A., 1981, Membrane separation: technological principles and issues, Trans. Am. Soc. Artif Intern. Organs, 27:345–350.PubMedGoogle Scholar
  47. 47.
    Zydney, A.L., Colton, C.K., 1984, A red cell deformation model for hemolysis in cross flow membrane plasmapheresis, Chem. Eng. Commun, 30:191–207.CrossRefGoogle Scholar
  48. 48.
    Rand, R.P., 1964, Mechanical properties of the red cell membrane. II. Viscoelastic break down of the membranes, Biophysical J., 4:303–316.CrossRefGoogle Scholar
  49. 49.
    Blackshear, P.L. Anderson, R.J., 1977, Hemolysis threshold in microporous techniques, Blood Cells, 3:377–390.Google Scholar
  50. 50.
    Ding, L.H., Jaffrin, M. Y., Gupta, B.B., 1986, A model of hemolysis in membrane plasmapheresis, Trans. Am. Soc. Artif. Int. Organs, 32:330–333.Google Scholar
  51. 51.
    Philp, J.L., Jaffrin, M.Y., Ding, L.H., 1994, Hemolysis during membrane plasma separation with pulsed flow filtration enhancement, J. of Biomechanical Eng., Trans. ASME, 116:514–520.CrossRefGoogle Scholar
  52. 52.
    Gurland, H.J., Lysaght, M.J., Samtleben, W., Schmidt, B., 1984, Comparative evaluation of filters used in membrane plasmapheresis, Nephron, 36:173–182.PubMedCrossRefGoogle Scholar
  53. 53.
    Lysaght, M.J., Samtleben, W., Schmidt, B., Gurland, H.J., 1983, Contemporary technical issues in membrane plasmapheresis: controversies and reconciliation, in Plasma Separation and Plasma Fractionation, Karger, Baser, 315-328.Google Scholar
  54. 54.
    Roberts, C.G., Schindhelm, K., Farrell, P.C., 1983, Protein membrane interactions in membrane plasma Separation, in Plasmapheresis, ed. by Nose Y., Malchesky P.S., Smith J.W., ISAO Press, Cleveland, 81–91.Google Scholar
  55. 55.
    Young, B.R., Pitt, W.G., Cooper, S.L., 1988, Protein adsorption on polymeric biomaterials. II — Adsorption kinetics, J. Colloid Interface Science, 125:246–253.CrossRefGoogle Scholar
  56. 56.
    Kaplan, A.E., Halley, S.E., 1988, Evaluation of a rotating filter for use with therapeutic plasma exchange, Trans. Am. Soc. Artif. Intern. Organs, 34:274–276.Google Scholar
  57. 57.
    Stromberg, R.R., Friedman, L.I., Schorr, J.B., 1991, Donor plasmapheresis technology, in Advances in Hemapheresis, ed. by C.Th. Smit Sibinga, L. Katers, Kiewer Academic Publish., Dordrecht, 29–38.CrossRefGoogle Scholar
  58. 58.
    Lysaght, M.J., Samtleben, W., Schmidt, B., Stoffner, D., Gurland, H.J., 1983, Spontaneous membrane plasmapheresis, Trans. Am. Soc. Artif. Intern. Organs, 29:506–510.PubMedGoogle Scholar
  59. 59.
    Schmidt, B., Lysaght, M.J., Samtleben, W., Gurland, H.J., 1983, Plasmapheresis without pumps for therapeutic and donor purposes, in Plasma separation and plasma fractionation, ed. by Lysaght M.J., Gurland H.J., Kerger Basil, 188-196.Google Scholar
  60. 60.
    Solem, J.O., Steen, S., Olin, C.A., 1986, A new method for autotransfusion of shed blood, Acta Chirurg. Scand., 152:421–425.Google Scholar
  61. 61.
    Legallais, C., Jaffrin, M. Y., 1993, A feasibility study of a filtration type autotransfusion device, J. Biomed. Eng., 15:143–147.PubMedCrossRefGoogle Scholar
  62. 62.
    Kalra, M., Beech, M.J., Al Khaffaf, H., Charlesworth, D., 1993, Autotransfusion in aortic surgery, the haemocell 350 cell saver system, Br. J. Surg., 80:32–35.PubMedCrossRefGoogle Scholar
  63. 63.
    Sakurai, H., Ozawa, K., Takesawa, S., Sakow, K., 1986, Design of a plasma separation using ceramic membranes, Trans. Am. Soc. Artif. Intern. Organs, 32:410–413.CrossRefGoogle Scholar
  64. 64.
    Ozawa, K., Kin, H.B., Sakurai, H., Takesawa, S., Sakai, K., 1986, Novel utilization of ceramic membranes in plasma treatment, in Progress in Artificial Organs, ed. by Nosè Y. et al., ISAO Press, 913-920.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • M. Y. Jaffrin
    • 1
  1. 1.URA CNRS 858, Dept of Biological EngineeringTechnological University of CompiègneCompiegne CedexFrance

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