Factors Controlling the Ion Conductance of Channels
Ion flow through membranes is not favored because it involves movement of charge through a low dielectric constant medium. The strong interaction between ions and the highly polarizable fluid, water, means that a great deal of energy is needed to remove ions from water. The low polarizability of the lipid environment in the membrane does not interact strongly with ions and therefore acts as a good barrier to ion flux. For these reasons, ion flux through membranes must be facilitated by a transport process or some polar defect in the membrane.
KeywordsBulk Phase Dextran Sulfate Alpha Helix Succinic Anhydride Access Resistance
Unable to display preview. Download preview PDF.
- R. Kleene, N. Pfanner, R. Pfaller, T.A. Link, W. Sebald and W. Neupert, EMBO J., 6, 2627 (1987).Google Scholar
- B. Hille, Ionic Channels of Excitable Membranes, Sinauer Assoc. Inc. Sunderland, MA, (1984) p. 184.Google Scholar
- J.A. Schafer and T.E. Andreoli in Membrane Physiology, 2nd, Edition, T.E. Andreoli, J.F. Hoffman, D.D. Fanestil and S.G. Schultz (Editors) Plenum Medical Book Co., New York, (1987), Chap. 11, p. 185.Google Scholar
- A. Finkelstein and A. Mauro in Cellular Biology of Neurons, E. R. Kandel (Editor), American Physiological Society, Bethesda MD, (1977), Vol. 1, p. 161.Google Scholar
- G. Eisenman and S. Krasne in MTP International Reviews of Science, Biochemistry Series, C.F. Fox (Editor), Butterworth, London, (1975), Vol. 2, p. 27.Google Scholar
- A.L. Hodgkin and A.F. Huxley, J. Physiol., 117, 500 (1952).Google Scholar