Subacute Toxicity of Cyclopiazonic Acid in Broiler Chicks Fed Normal and High Zinc Diets
Cyclopiazonic acid (CPA) was first isolated and identified as a toxic metabolite of Penicillium cyclopium Westling (Holzapfel, 1968). Corn and peanuts may be naturally contaminated with both CPA and aflatoxin B1 (Gallagher et al., 1978; Lansden and Davidson, 1983). Cyclopiazonic acid was relatively toxic in most animal studies (Purchase, 1971; Dorner et al., 1983; Lomax et al., 1984; Morrissey et al., 1984; Morrissey et al., 1985; Nuehring et al., 1985; Cullen et al., 1988; Wilson et al., 1989) and the 72 hr oral LD50 of CPA in day-old broiler chicks was 12 mg/kg body weight (BW) (Wilson et al., 1989).
KeywordsBroiler Chicken Plasma Zinc Dietary Zinc Cyclopiazonic Acid Broiler Chick
Unable to display preview. Download preview PDF.
- Cullen, J.M., Wilson, M.E., Hagler, W.M., Jr., Ort, J.F., and Cole, R.J. (1988). Histologic lesions in broiler chicks given cyclopiazonic acid orally. Amer. J. Vet. Res., 49, 728–731.Google Scholar
- Dorner, J.W., Cole, R.J., Lomax, L.G., Gosser, H.S., and Diener, U.L. (1983). Cyclopiazonic acid production by Aspergillus flavus and its effects on broiler chickens. Appl. Environ. Microbiol., 46, 698–703.Google Scholar
- Lansden, J.A. and Davidson, J.I. (1983). Occurrence of cyclopiazonic acid in peanuts. Appl. Environ. Microbiol., 45, 766–769.Google Scholar
- Lomax, L.G., Cole, R.J., and Dorner, J.W. (1984). The toxicity of cyclopiazonic acid in weaned pigs. Vet. Pathol., 21, 418–424.Google Scholar
- Morrissey, R.E., Cole, R.J., and Dorner, J.W. (1984). The effects of cyclopiazonic acid on pregnancy and fetal development of Fischer rats. J. Toxicol. Environ. Health. 14, 585–594.Google Scholar
- Nuehring, L.P., Rowland, G.N., Harrison, L.R., Cole, R.J., and Dorner, J.W. (1985). Cyclopiazonic acid mycotoxicosis in the dog. Amer. J. Vet. Res., 46, 1670–1676.Google Scholar
- SAS. (1982). SAS User’s Guide. Statistics. Statistical Analysis System Institute, Inc., Cary, NC.Google Scholar