Zinc and Hormones

  • Ananda S. Prasad
Part of the Biochemistry of the Elements book series (BOTE, volume 11)


Zinc supplementation studies first performed in Egypt demonstrated reversible growth retardation in zinc-deficient human subjects (Prasad, 1966; Sandstead et al., 1967). Following zinc supplementation, the average increment in height in male subjects between the ages of 14 and 20 (average 17 years) was 5.0 inches per year. Biochemical studies were consistent with the concept that the growth retardation in these subjects was the result of deficiency of zinc.


Androgen Receptor Zinc Deficiency Zinc Level Zinc Supplementation Plasma Zinc 
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  1. Abbasi, A. A., Prasad, A. S., Ortega, J., Congco, E., and Oberleas, D., 1976. Gonadal function abnormalities in sickle cell anemia: Studies in adult male patients, Ann. Intern. Med. 85: 601.Google Scholar
  2. Aihara, K., Nishi, Y., Hatano, S., Kihara, M., Yoshimutsu, K., Takeichi, N., Ito, T., Ezaki, H., and Usui, T., 1984. Zinc, copper, manganese and selenium metabolism in thyroid disease, Am. J. Clin. Nutr. 40: 26.Google Scholar
  3. Aihara, K., Nishi, Y., Hatano, S., Kihara, M., Ohta, M., Sakoda, K., Uozumi, T., and Usui, T., 1985. Zinc, copper, manganese, and selenium metabolism in patients with human hormone deficiency or acromegaly, J. Pediatr. Gastroenterol. Nutr. 4: 610.CrossRefGoogle Scholar
  4. Arquilla, E., Packer, S., Tarmas, W., and Miyamoto, S., 1978. The effect of zinc on insulin metabolism, Endocrinology 103: 1440.CrossRefGoogle Scholar
  5. Baraldi, M., Caselgrandi, E., and Sauti, M., 1984. Reduction of withdrawal symptoms in morphine-dependent rats by zinc: Behavioral and biochemical studies, Neurosci. Lett. Suppl. 18: 5371.Google Scholar
  6. Berkenbush, F., Oers, J. V., Rey, A. D., Tilders, F., and Besdedoksy, H., 1987. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1, Science 238: 524.CrossRefGoogle Scholar
  7. Bernton, E. S., Beach, J. E., Holaday, J. W., Smallridge, R. C., and Fein, H. G., 1987. Release of multiple hormones by a direct action of interleukin-1 on pituitary cells, Science 238: 519.CrossRefGoogle Scholar
  8. Bjorndahl, L., and Kvist, U., 1982. Importance of zinc for human sperm head—tail connection, Acta Physiol. Scand. 116: 51.CrossRefGoogle Scholar
  9. Bolze, M. S., Reeves, R. D., Lindbeck, F. E., and Elders, M. J., 1987. Influence of zinc on growth, somatomedin, and glycosaminoglycan metabolism in rats, Am. J. Physiol. 252: E2 I.Google Scholar
  10. Bremner, W. F., and Fell, G. S., 1977. Zinc metabolism and thyroid status, Postgrad. Med. J. 53: 143.CrossRefGoogle Scholar
  11. Butrimovitz, G. P., and Purdy, W. C., 1978. Zinc nutrition and growth in a childhood population, Am. J. Clin. Nutr. 31: 1409.Google Scholar
  12. Castro-Magana, M., Collipp, P. J., Chen, S. Y., Cheruvanky, T., and Maddaiah, V. T., 1981. Zinc nutritional status, androgens, and growth retardation, Am. J. Clin. Nutr. 135: 322.Google Scholar
  13. Cavdar, A. O., Arcasoy, A., Cin, S., and Gumus, H., 1980. Zinc deficiency in geophagia in Turkish children and response to treatment with zinc sulphate, Haematologica 65: 403.Google Scholar
  14. Chan, W., Bates, J. M., Chung, K. W., and Rennert, O. M., 1986. Abnormal zinc metabolism in unilateral maldescended testis of mutant rat strain, Proc. Soc. Exp. Biol. Med. 182: 549.Google Scholar
  15. Chang, C., Kokontis, J., and Liao, S., 1988a. Molecular cloning of human and rat complementary DNA encoding androgen receptors, Science 240: 324.CrossRefGoogle Scholar
  16. Chang, C., Kokontis, J., and Liao, S., 1988b. Structural analysis of complementary DNA and amino acid sequences of human and rat androgen receptors, Proc. Natl. Acad. Sei. USA 85: 7211.CrossRefGoogle Scholar
  17. Cherry, F. F., Sandstead, H. H., Rojas, P., Johnson, L. K., Batson, H. K., and Wang, X. B., 1989. Adolescent pregnancy. Associations among body weight, zinc nutriture, and pregnancy out-come, Am. J. Clin. Nutr. 50: 945.Google Scholar
  18. Cheruvanky, T., Castro-Magana, M., Chen, S. Y., Collipp, P. J., and Ghavami-Maibodi, Z., 1982. Effect of growth hormone on hair, serum, and urine zinc in growth hormone-deficient children, Am. J. Clin. Nutr. 35: 668.Google Scholar
  19. Chester, J. K., 1978. Biochemical functions of zinc in animals, World Rev. Nutr. Diet. 32: 135.Google Scholar
  20. Chung, K. W., Kim, S. Y., Chan, W., and Rennert, O. M., 1986. Androgen receptors in ventral prostate glands of zinc deficient rats, Life Sci. 38: 351.CrossRefGoogle Scholar
  21. Collip, P. J., Castro-Magana, M., Petrovic, M., Thomas, J., and Cheruvanky, T., 1982. Zinc deficiency: Improvement in growth and growth hormone levels with oral zinc therapy, Ann. Nutr. Metab. 26: 287.CrossRefGoogle Scholar
  22. Colvard, D. S., and Wilson, E. M., 1984. Zinc potentiation of androgen receptor binding to nuclei in vitro, Biochemistry 23: 3471.CrossRefGoogle Scholar
  23. Coulston, L., and Dandone, P., 1980. Insulin-like effect of zinc on adipocytes, Diabetes 29: 665.CrossRefGoogle Scholar
  24. Cunnane, S. C., 1981, Inhibition of arachidonic acid metabolism in the uteri of zinc deficient parturient rats, Proc. Nutr. Soc. 40: 78A.Google Scholar
  25. Cunnane, S. C., Majid, E., Senior, J., and Mills, C. F., 1983. Utero-placental dysfunction and prostaglandin metabolism in zinc-deficient pregnant rats, Life Sci. 32: 2471.CrossRefGoogle Scholar
  26. Cunningham, B. C., Bass, S., Fuh, G., and Wells, J. A., 1990. Zinc mediation of the binding of human growth hormone to the human prolactin receptor, Science 250: 1709.CrossRefGoogle Scholar
  27. Disteche, C. M., Casanova, M., Saal, H., Friedman, C., Sybert, V., Graham, J., Thuline, H., Page D. C., Fellovs M., 1986. Small deletions of the short arm of the Y chromosome in 46, XY females, Proc. Natl. Acad. Sci, USA 83: 7841.CrossRefGoogle Scholar
  28. Dunn, M. A., Blalock, T. L., and Cousins, R. J., 1987. Metallothionein, Proc. Soc. Exp. Biol. Med. 185: 107.Google Scholar
  29. Engelbart, K., and Kief, H., 1970. Uber das funktionelle Verhalten von Zinc und Insulin in den B-Zellen des rathen Pankreas, Virchows Arch. B 4: 294.Google Scholar
  30. Erickson, R. P., and Verga, V., 1989. Mini review: Is zinc-finger y the sex-determining gene ? Am. J. Hum. Genet. 45: 671.Google Scholar
  31. Floersheim, G. L., Bianchi, L., Probst, A., Chiodetti, N., and Haneggen, C. G., 1984. Influence of zinc-d-penicillamine and oxygen on poisoning with Amantia phalloides: Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom, Agents Actions 14: 124.CrossRefGoogle Scholar
  32. Ghavami-Maibodi, S. Z., Collip, P. J., Castro-Magana, M., Stewart, C., and Chen, S. Y., 1983. Effect of oral zinc supplements on growth, hormonal levels, and zinc in healthy short children, Ann. Nutr. Metab. 27: 214.CrossRefGoogle Scholar
  33. Gibson, R. S., Vanderkooy, P. D. S., MacDonald, A. C., Goldman, A., Ryan, B. A., and Berry, M., 1989. A growth-limiting mild zinc deficiency syndrome in some South Ontario boys with low weight percentiles, Am. J. Clin. Nutr. 49: 1266.Google Scholar
  34. Gold, G., and Grodsky, G. M., 1984. Kinetic aspects of compartmental storage and secretion of insulin and zinc, Experientia 40: 1105.CrossRefGoogle Scholar
  35. Gordon, J., Morlet, J. E., and Hershman, J. M., 1979. Thyroid function and zinc deficiency, Clin. Res. 27: 20A.Google Scholar
  36. Gourmelen, M., Pham-Huu-Trung, M. T., and Girard, F., 1979. Transient partial hGH deficiency in prepubertal children with delay of growth, Pediatr. Res. 13: 221.CrossRefGoogle Scholar
  37. Grant, P. T., Coombs, T. L., and Frank, B. H., 1972. Differences in the nature of the interaction of insulin and proinsulin with zinc, Biochem. J. 126: 433.Google Scholar
  38. Guigliano, R., and Millward, D. J., 1987. The effects of severe zinc deficiency on protein turnover in muscle and thymus, Br. J. Nutr. 57: 139.CrossRefGoogle Scholar
  39. Gunn, S. A., Gould, T. C., and Anderson, W. A. D., 1965. The effect of growth hormone and prolactin preparations on the control by interestitial cell-stimulating hormone of uptake of zinc-65 by the rat dorsolateral prostate, J. Endocrinol. 32: 205.Google Scholar
  40. Hager, M. H., 1986. Zinc deficiency compromises the adrenal response to sodium deprivation in rats, Nutr. Rep. Int. 34: 141.Google Scholar
  41. Halsted, J. A., Ronaghy, H. A., Abadi, P., Haghshenass, M., Amirhakemi, G. H., Barakat, R. M., and Reinhold, J. G., 1972. Zinc deficiency in man: The Shiraz experiment, Am. J. Med. 53: 277.Google Scholar
  42. Hambidge, K. M., and Walravens, P. A., 1976. Zinc deficiency in infants and preadolescent children, in Trace Elements in Human Health and Disease ( A. S. Prasad, ed.), Academic Press, New York, p. 21.Google Scholar
  43. Harper, M. E., Danutra, V., Chanduer, J. A., and Griffith, K., 1976. The effect of 2-bromo-alphaergocryptine (CB 154) administration on the hormone levels, organ weights, prostatic morphology and zinc concentrations in the male rat, Acta Endocrinol. (Copenhagen) 83: 211.Google Scholar
  44. Hartome, T. R., Sotaniemi, E. A., and Maatanen, J., 1979. Effect of zinc on some biochemical indices of metabolism, Nutr. Metab. 23: 294.CrossRefGoogle Scholar
  45. Henkin, R. I., 1974a. On the role of adrenocorticosteroids in the control of zinc and copper metabolism, in Trace Element Metabolism in Animals, Volume 2 ( W. G. Hoekstra, J. W., Suttie, H. E. Ganther, and W. Mertz, eds.), University Park Press, Baltimore, p. 647.Google Scholar
  46. Henkin, R. I., 1974b. Growth hormone-dependent changes in zinc and copper metabolism in man, in Trace Element Metabolism in Animals, Volume 2 ( W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds.), University Park Press, Baltimore, p. 653.Google Scholar
  47. Henkin, R. I., 1984. Zinc in taste function: A critical review, Biol. Trace Elem. Res. 6: 263.CrossRefGoogle Scholar
  48. Herrington, A. C., 1985. Effect of zinc on insulin binding to rat adipocytes and hepatic membranes and to human placental membranes and IM-9 lymphocytes, Horm. Metab. Res. 17: 328.CrossRefGoogle Scholar
  49. Judd, A. M., Macleod, R. M., and Login, I. S., 1984. Zinc may regulate pituitary prolactin secretion, in The Neurobiology of Zinc, Part A (C. J. Fredrickson, G. A. Howell, and E. J. Kasarskis, eds.), Liss, New York, p. 91.Google Scholar
  50. Kinlaw, W. B., Levine, A. S., Morley, J. E., Silvis, S. E., and McClain, C. J., 1983. Abnormal zinc metabolism in type II diabetes mellitus, Am. J. Med. 75: 273.Google Scholar
  51. Kirchgessner, M., and Roth, H. P., 1980. Biochemical changes of hormones and metalloenzymes in zinc deficiency, in Zinc in the Environment, Part II (J. O. Nriagu, ed.), Wiley, New York, p. 72.Google Scholar
  52. Kurtoglu, S., Patiroglu, T. E., and Karakas, S. E., 1987. Effect of growth hormone in epiphyseal growth plates in zinc deficiency, Tokai J. Clin. Med. 12: 325.Google Scholar
  53. Kvist, U., 1982. Spermatozoal thiol-disulphide interaction: A possible event underlying physiological sperm nuclear chromatin decondensation, Acta Physiol. 115: 503.CrossRefGoogle Scholar
  54. Leake, A., Chisholm, G. D., and Habib, F. K., 1984. The effect of zinc on the 5-alpha-reduction of testosterone by the hyperplastic human prostate gland, J. Steroid Biochem. 20: 651.CrossRefGoogle Scholar
  55. Lee, H. H., Prasad, A. S., Brewer, G. J., and Owyang, C., 1989. Zinc absorption in human small intestine, Am. J. Physiol. 256: G87.Google Scholar
  56. Lei, K. Y., Abbasi, A. A., and Prasad, A. S., 1976. Function of pituitary-gonadal axis in zinc-deficient rats, Am. J. Physiol. 230: 1730.Google Scholar
  57. Levine, A. S., McClain, C. J., Handwerger, B. S., Brown, D. M., and Morley, J. E., 1983. Tissue zinc status of genetically diabetic and streptozotocin induced diabetic mice, Am. J. Clin. Nutr. 37: 382.Google Scholar
  58. Login, I. S., Thorner, M. O., and Macleod, P. M., 1983. Zinc may have a physiological role in regulating pituitary prolactin secretion, Neuroendocrinology 37: 317.CrossRefGoogle Scholar
  59. Lubahn, D. B., Joseph, R. D., Sullivan, P. M., Willard, H. F., French, F. S., and Wilson, E. M., 1988. Cloning of human androgen receptor complementary DNA and localization to the X chromosome, Science 240: 327.CrossRefGoogle Scholar
  60. Ludvigsen, C., McDaniel, M., and Lacy, P. E., 1979. The mechanism of zinc uptake in isolated islets of Langerhans, Diabetes 28: 570.Google Scholar
  61. McClain, C. J., Gavaler, J. S., and VanThiel, D. H., 1984. Hypogonadism in the zinc-deficient rat: Localization of the functional abnormalities, J. Lab. Clin. Med. 104: 1007.Google Scholar
  62. McConnell, R. J., Blair-Stanek, C. S., and Rivlin, R. S., 1977. Decreased intestinal transport of zinc in hypothyroidism, Clin. Res. 25: 658A.Google Scholar
  63. Mahajan, S. K., Abbasi, A. A., Prasad, A. S., Rabbani, P., Briggs, W. A., and McDonald, F. D., 1982. Effect of oral zinc therapy on gonadal function in hemodialysis patients. A double-blind study, Ann. Intern. Med. 97: 357.Google Scholar
  64. Mahajan, S. K., Hamburger, R. J., Flamenbaum, W., Prasad, A. S., and McDonald, F. D., 1985. Effect of zinc supplementation on hyperprolactinemia in uremic men, Lancet 2: 750.CrossRefGoogle Scholar
  65. Malette, L. E., and Henkin, R. I., 1976. Altered copper and zinc metabolism in primary hyper-parathyroidism, Am. J. Med. Sci. 272: 167.CrossRefGoogle Scholar
  66. Meftah, S. P., Prasad, A. S., DuMouchelle, E., Cossack, Z. T., and Rabbani, P., 1984. Testicular androgen binding protein in zinc-deficient rats, Nutr. Res. 4: 437.CrossRefGoogle Scholar
  67. Morley, J. E., Gordon, J., and Hershman, J. M., 1980. Zinc deficiency, chronic starvation and hypothalamic-pituitary-thyroid function, Am. J. Clin. Nutr. 33: 1767.Google Scholar
  68. Morley, J. E., Russell, R. M., Reed, A., Carney, E. A., and Hershman, J. M., 1981. The interrelationship of thyroid hormones with vitamin A and zinc nutritional status in patients with chronic hepatitis and gastrointestinal disorders, Am. J. Clin. Nutr. 34: 1489.Google Scholar
  69. Nagamine, C. M., Chan, K., Kozak, C. A., and Lau, Y. F., 1989. Chromosome mapping and expression of a putative testis determining gene in mouse, Science 243: 80.CrossRefGoogle Scholar
  70. Neggers, Y. H., Cutter, R., Acton, R. T., Alvarez, J. O., Bonner, J. L., Goldenberg, R. L., Go, R. C. P., and Roseman, J. M., 1990. A positive association between maternal serum zinc concentration and birth weight, Am. J. Clin. Nutr. 51: 678.Google Scholar
  71. Neill, H. B., Leach, B. E., and Kraus, A. P., 1979. Zinc metabolism in sickle cell anemia, J. Am. Med. Assoc. 242: 2686.CrossRefGoogle Scholar
  72. Nishi, Y., Hatano, S., Aihara, K., Fujie, A., and Kihara, M., 1989. Transient partial growth hormone deficiency due to zinc deficiency, J. Am. Coll. Nutr. 8: 93.Google Scholar
  73. Page, D. C., 1988. Is ZFY the sex-determining gene on the human Y chromosome? Philos. Trans. R. Soc. London 322: 155.CrossRefGoogle Scholar
  74. Page, D. C., Mosher, R., Simpson, E. M., Fisher, E. M. C., Mardon, G., Pollack, J., and McGillivray, B., 1987. The sex-determining region of the human Y chromosome encodes a finger protein, Cell 51: 1091.CrossRefGoogle Scholar
  75. Pai, L. H., and Prasad, A S, 1988. Cellular zinc in patients with diabetes mellitus, Nutr. Res. 8: 889.CrossRefGoogle Scholar
  76. Park, J. H. Y., Grandjean, C. T., Hart, M. H., Erdman, S. H., Pour, P., and Vanderhof, J. A., 1986. Effect of pure zinc deficiency on glucose tolerance and insulin and glucagon levels, Am. J. Physiol. 251: E273.Google Scholar
  77. Prasad, A. S., 1966. Metabolism of zinc and its deficiency in human subjects, in Zinc Metabolism ( A. S. Prasad, ed.), Thomas, Springfield, Ill., p. 250.Google Scholar
  78. Prasad, A. S., 1981. Zinc deficiency and effects of zinc supplementation on sickle cell anemia subjects, in The Red Cell: Fifth Ann Arbor Conference ( G. J. Brewer, ed.), Liss, New York, p. 99.Google Scholar
  79. Prasad, A. S., and Cossack, Z. T., 1984. Zinc supplementation and growth in sickle cell disease, Ann. Intern. Med. 100: 367.Google Scholar
  80. Prasad, A. S., Halsted, J. A., and Nadimi, M., 1961. Syndrome of iron deficiency anemia, he patosplenomegaly, hypogonadism, dwarfism and geophagia, Am. J. Med. 31: 532.CrossRefGoogle Scholar
  81. Prasad, A. S., Miale, A., Farid, Z., Sandstead, H. H., Schulert, A. R., and Darby, W. J., 1963a. Biochemical studies on dwarfism, hypogonadism and anemia, Arch. Intern. Med. 111: 407.CrossRefGoogle Scholar
  82. Prasad, A S., Miale, A., Farid, Z., Schulert, A., and Sandstead, H. H., 1963b. Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypogonadism, J. Lab. Clin. Med. 61: 537.Google Scholar
  83. Prasad, A. S., Oberleas, D., Wolf, P., and Horwitz, J. P., 1969. Effect of growth hormone on nonhypophysectomized rats, J. Lab. Clin. Med. 73: 486.Google Scholar
  84. Prasad, A. S., Schoomaker, E. B., Ortega, J., Brewer, G. J., Oberleas, D., and Oelschlegel, F. J., 1975. Zinc deficiency in sickle cell disease, Clin. Chem. 21: Washington, D.C., 582.Google Scholar
  85. Prasad, A. S., Fernandez-Madrid, F., and Ryan, J. F., 1979. Deoxythymidine kinase activity of human implanted sponge connective tissue in zinc deficiency, Am. J. Physiol. 263 (3): E272.Google Scholar
  86. Prasad, A. S., Abbasi, A. A., Rabbani, P., and DuMouchelle, E., 1981. Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects, Am. J. Hematol. 19: 119.CrossRefGoogle Scholar
  87. Quarterman, J., 1974. The effects of zinc deficiency or excess on the adrenals and the thymus of the rat, in Trace Element Metabolism in Animals, Volume 2 ( W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds.), University Park Press, Baltimore, p. 742.Google Scholar
  88. Reeves, P. G., Frissell, S. G., and O’Dell, B. L., 1977. Response of serum corticosterone to ACTH and stress in the zinc deficient rat, Proc. Soc. Exp. Biol. Med. 156: 500.Google Scholar
  89. Rillema, J. A., 1979. Effect of zinc ions on the actions of prolactin on RNA and casein synthesis in mouse mammary gland explants, Proc. Soc. Exp. Biol. Med. 162: 464.Google Scholar
  90. Robinson, L. K., and Hurley, L. S., 1981. Effect of maternal zinc deficiency of food restriction on rat fetal pancreas, J. Nutr. 111: 869.Google Scholar
  91. Roth, H., and Kirchgessner, M., 1981. Zinc and insulin metabolism, Biol. Trace Elem. Res. 3: 13.CrossRefGoogle Scholar
  92. Sandstead, H. H., Prasad, A. S., Schulert, A. R., Farid, Z., Miale, A., Bassilly, S., and Darby, W. J., 1967. Human zinc deficiency, endocrine manifestations and response to treatment, Am. J. Clin. Nutr. 20: 422.Google Scholar
  93. Sapolsky, R., Rivier, C., Yamamoto, G., Plotsky, P., and Vale, W., 1987. Interleukin- I stimulates the secretion of hypothalamic corticotropin-releasing factor, Science 238: 522.CrossRefGoogle Scholar
  94. Scott, D. A., 1934. Crystalline insulin, Biochem. J. 28: 1592.Google Scholar
  95. Scott, D. A., and Fisher, A. M., 1938. The insulin and zinc content of normal and diabetic pancreas, J. Clin. Invest. 17: 725.CrossRefGoogle Scholar
  96. Simmer, K., Khanum, S., Carlsson, L., and Thompson, R. P., 1988. Nutritional rehabilitation in Bangladesh: The importance of zinc, Am. J. Clin. Nutr. 47: 1036.Google Scholar
  97. Solomons, N. W., Rosenfeld, R. L., Jacob, R. A., and Sandstead, H. H., 1976. Growth retardation and zinc nutrition, Pediatr. Res. 10: 923.CrossRefGoogle Scholar
  98. Stalvey, J. R. D., and Erickson, R. P., 1987. Inheritance of the sex-determining factor in the absence of a complete Y chromosome in 46, XX human males, Ann. N.Y. Acad. Sci. 513: 505.CrossRefGoogle Scholar
  99. Stengaard-Pederson, K., 1982. Inhibition of enkephalin binding to opiate receptors by zinc ions: Possible physiological importance for the brain, Acta Pharmacol. Toxicol. 50: 213.CrossRefGoogle Scholar
  100. Stengaard-Pederson, K., Fredens, K., and Larsson, L. I., 1981. Enkephalin and zinc in the hip-pocampal mossy fibre system, Brain Res. 212: 230.CrossRefGoogle Scholar
  101. Stengaard-Pederson, K., Larsson, L. I., Fredeno, K., and Rehfeld, J. F., 1984. Modulation of cholecystokinin concentrations in the rat hippocampus by chelation of heavy metals, Proc. Natl. Acad. Sci. USA 81: 5876.CrossRefGoogle Scholar
  102. Wallwork, J. C., Botnen, J. H., and Sandstead, H. H., 1982. Effect of dietary zinc on rat brain catecholamines, J. Nutr. 112: 514.Google Scholar
  103. Walravens, P. A., Hambidge, K. M., and Koepfer, D. M., 1989. Zinc supplementation in infants with a nutritional pattern of failure to thrive: A double-blind controlled study, Pediatrics 83: 532.Google Scholar
  104. Warth, J. A., Prasad, A S., Zwas, F., and Frank, R. N., 1981. Abnormal dark adaptation in sickle cell anemia, J. Lab. Clin. Med. 98: 189.Google Scholar
  105. Watanabe, T., Salo, F., and Endo, A., 1983. Cytogenetic effects of zinc deficiency on oogenesis and spermatogenesis in mice, Yamagata Med. J. 1: 13.Google Scholar
  106. Xue-Cun, C., Tai-An, Y., Jin-Sheng, H., Qiu-Yan, M., Zhi-Min, H., and Li-Xiang, L., 1985. Low levels of zinc in hair and blood pica, anorexia, and poor growth in Chinese preschool children, Am. J. Clin. Nutr. 42: 694.Google Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ananda S. Prasad
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, Division of Hematology and OncologyWayne State University School of MedicineUSA
  2. 2.Harper HospitalDetroitUSA
  3. 3.Veterans Administration Medical CenterAllen ParkUSA

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