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Biochemistry of Metallothionein

  • Ananda S. Prasad
Part of the Biochemistry of the Elements book series (BOTE, volume 11)

Abstract

Historically the term metallothionein (MT) has been used to designate the Cd-, Zn-, and Cu-containing sulfur-rich protein from equine renal cortex (Kagi and Vallee, 1960). The major characteristics of this protein were defined by Kagi et al. (1974) and Kojima et al. (1976).

Keywords

Toxic Trace Element Thiolate Ligand Metal Thiolate Mammalian Form Metallothionein Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Andrews, G. K., Adamson, E. D., and Gedam, L., 1984. The ontogeny of expression of murine metallothionein: Comparison with the alpha-fetoprotein gene, Dey. Biol. 103: 294.CrossRefGoogle Scholar
  2. Angel, P., Poting, A., Mallick, U., Rahmsdor, H. J., Schorpp, M., and Herrlich, P., 1986. Induction of metallothionein and other messenger-RNA species by carcinogens and tumor promoters in primary human skin fibroblasts, Mol. Cell. Biol. 6 (5): 1760.Google Scholar
  3. Bakka, A., and Webb, M., 1981. Metabolism of zinc and copper in neonate: Changes in the concentrations and contents of thionein-bound Zn and Cu with age in the livers of the newborn of various mammalian species, Biochem. Pharmacol. 30: 721.CrossRefGoogle Scholar
  4. Beltramini, M., and Lerch, K., 1982. Copper transfer between Neurospora copper metallothionein and type 3 copper apoprotiens, FEBS Leu. 142: 219.CrossRefGoogle Scholar
  5. Bernhard, W. R., Vasak, M., and Kagi, J. H. R., 1986. Cadmium binding and metal cluster formation in metallothionein: A differential modification study, Biochemistry 25: 1975.CrossRefGoogle Scholar
  6. Braun, W., Wagner, G., Worgotter, E., Vasak, M., Kagi, J. H. R., and Wuthrich, K., 1986. Polypeptide fold in the two metal clusters of metallothionein-2 by nuclear magnetic resonance in solution, J. Mol. Biol. 187: 125.CrossRefGoogle Scholar
  7. Bremner, I., and Morrison, J. N., 1988. Metallothionein as an indicator of zinc status, in Essential and Toxic Trace Elements in Human Health and Disease ( A. S. Prasad, ed.), Liss, New York, p. 365.Google Scholar
  8. Brewer, G. J., Hill, G. M., Prasad, A. S., Cossack, Z. T., and Rabbani, P., 1983. Oral zinc therapy for Wilson’s disease, Ann. Intern. Med. 99: 314.Google Scholar
  9. Butt, T. R., and Ecker, D. J., 1987. Yeast metallothionein and application in biotechnology, Microbiol. Rev. 51: 351.Google Scholar
  10. Compere, S. J., and Palmiter, R. D., 1981. DNA methylation controls the inducibility of mouse metallothionein-I gene in lymphoid cells, Cell 25: 233.CrossRefGoogle Scholar
  11. Cousins, R. J., 1983. Metallothionein-Aspects related to copper and zinc metabolism, J Inher. Metab. Dis. 6 (Suppl 1): 15.CrossRefGoogle Scholar
  12. Cousins, R. J., Dunn, M. A., Leinart, A. S., Yedinak, K. C., and DiSilvestro, R. A., 1986. Coordinate regulation of zinc metabolism and metallothionein gene expression in rats, Am. J. Physiol. 251: E688.Google Scholar
  13. Crawford, B. D., Enger, M. D., Griffith, B. B., Griffith, J. D., Hanners, J. L., Longmire, J. L., Munk, A. C., Stallings, R. L., Tesmer, J. G., Walkers, R. A., and Hildebrand, C. E., 1985. Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: Implications for mechanisms regulating metallothionein gene expression, Mol. Cell. Biol. 5: 320.Google Scholar
  14. Dunn, M. A., Blalock, T. L., and Cousins, R. J., 1987. Proc. Soc. Exp. Biol. Med. Metallothionein 185: 107.Google Scholar
  15. Forre, A. O., Aaseth, J., Dobloug, J., and Ovreb, 0., 1982. Induction of a metallothionein-like protein in human lymphocytes, Scand. J. Immunol. 15: 217.Google Scholar
  16. Fowler, B. A., Hildebrand, C. E., Kojima, Y., and Webb, M., 1987. Nomenclature of metallothionein, Experientia Suppl. 52: 19.Google Scholar
  17. Furey, W. F., Robbins, A. H., Clancy, L. L., Winge, D. R., Wang, B. C., and Stout, C. D., 1986. Crystal structure of Cd, Zn metallothionein, Science 231: 704.CrossRefGoogle Scholar
  18. Grider, A., Kao, K., Klein, P. A., and Cousins, R. J., 1989. Enzyme-linked immunosorbent assay for human metallothionein: Correlation of induction with infection, J. Lab. Clin. Med. 113: 221.Google Scholar
  19. Huber, M., and Lerch, K., 1987. The influence of copper on the induction of tyrosinase and laccase in Neurospora crassa, FEBS Lett. 219: 335.CrossRefGoogle Scholar
  20. Hunziker, P. E., and Kagi, J. H. R., 1988. Metallothionein: A multigene protein, in Essential and Toxic Trace Elements in Human Health and Disease ( A. S. Prasad, ed), Liss, New York, p. 349.Google Scholar
  21. Kagi, J. H. R., and Nordberg, M., 1979. Metallothionein, Experientia Suppl. 34: 41.Google Scholar
  22. Kagi, J. H. R., and Schaffer, A., 1988. Biochemistry of metallothionein, Biochemistry 27: 8509.CrossRefGoogle Scholar
  23. Kagi, J. H. R., and Vallee, B. L., 1960. Metallothionein: A cadmium-and zinc-containing protein from equine renal cortex, J. Biol. Chem. 235: 3460.Google Scholar
  24. Kagi, J. H. R., Himmelhoch, S. R., Whanger, P. D., Bethune, J. L., and Vallee, B. L., 1974. Equine hepatic and renal metallothioneins, J. Biol. Chem. 249: 3537.Google Scholar
  25. Kelley, S. L., Basu, A., Teicher, B. A., Hacker, M. P., Hamer, D. H., and Lazo J S 1988. Overexpression of metallothionein confers resistance to anticancer drugs, Science 241: 181 3.Google Scholar
  26. Kojima, Y., Berger, C., Vallee, B. L., and Kagi, J. H. R., 1976. Amino-acid sequence of equine renal metallothionein-1B, Proc. Natl. Acad. Sci. USA 73: 3413.CrossRefGoogle Scholar
  27. Margoshes, M., and Vallee, B. L., 1957. A cadmium protein from equine kidney cortex, J. Am. Chem. Soc. 79: 4813.CrossRefGoogle Scholar
  28. Mehra, R. K., and Bremner, I., 1983. Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys, Biochem. J. 213: 459.Google Scholar
  29. Nemer, M., Travaglini, E. C., Rondinell, E., and D’Alonzo, J., 1984. Developmental regulation, induction, and embryonic tissue specificity of sea urchin metallothionein gene expression, Dey. Biol. 102: 471.CrossRefGoogle Scholar
  30. Ohtake, H., Haswgawa, K., and Koga, M., 1978. Zinc-binding protein in the livers of neonatal, normal and partially hepatectomized rats, Biochem. J. 174: 999.Google Scholar
  31. Palmiter, R. D., 1987. Molecular biology of metallothionein gene expression, Experientia Suppl. 52: 63.Google Scholar
  32. Palmiter, R. D., and Brinster, R. L., 1985. Transgenic mice, Cell 41: 343.CrossRefGoogle Scholar
  33. Palmiter, R. D., Norstedt, G., Gelinas, R. E., Hammer, R. E., and Brinster, R. L., 1983. Metallothionein-human GH fusion genes stimulate growth of mice, Science 222: 809.CrossRefGoogle Scholar
  34. Patierno, S. R., and Peavy, D. L., 1984. Induction of metallothionein in macrophages: A molecular mechanism for protection against LPS-mediated autolysis, Immunopharmacol. Endotoxicosis 39.Google Scholar
  35. Patierno, S. R., Costa, M., Lewis, V. M., and Peavy, D. L., 1983. Inhibition of LPS toxicity for macrophages by metallothionein-inducing agents, J. Immunol. 130: 1924.Google Scholar
  36. Piscator, M., 1964. On cadmium in normal human kidneys together with a report on the isolation of metallothionein from livers of cadmium-exposed rabbits, Nord. Hyg. Tidskr. 45: 76.Google Scholar
  37. Pulido, P., Kagi, J. H. R., and Vallee, B. L., 1966. Isolation and some properties of human metallothionein, Biochemistry 5: 1768.CrossRefGoogle Scholar
  38. Richards, M. P., and Cousins, R. J., 1975. Mammalian zinc homeostasis: Requirement for RNA and metallothionein synthesis, Biochem. Biophys. Res. Commun. 64: 1215.CrossRefGoogle Scholar
  39. Seguin, C., and Hamer, D. H., 1987. Regulation in vitro of metallothionein gene binding factors, Science 235: 1383.CrossRefGoogle Scholar
  40. Shaikh, Z. A., and Smith, J. C., 1975a. Cadmium induced synthesis of hepatic and renal metallothionein, Fed. Proc. 34: 266.Google Scholar
  41. Shaikh, Z. A., and Smith, J. C., 1975b. Mercury-induced synthesis of renal metallothionein, International Conference on Heavy Metals in the Environment, Abstracts, Toronto, Canada, October, 1975, p. B 108.Google Scholar
  42. Shaikh, Z. A., and Smith, J. C., 1977. The mechanisms of hepatic and renal metallothionein biosynthesis in cadmium-exposed rats, Chem. Biol. Interact. 19: 161.CrossRefGoogle Scholar
  43. Shiraishi, N., Yamamoto, H., Takeda, Y., Kondoh, S., Hayashi, H., Hashimoto, K., and Aono, K., 1986. Increased metallothionein content in rat liver and kidney following X-irradiation, Toxicol. Appl. Pharmacol. 85: 128.CrossRefGoogle Scholar
  44. Squibb, K. S., and Cousins, R. J., 1974. Control of cadmium binding protein synthesis in rat liver, Environ. Physiol. Biochem. 4: 24.Google Scholar
  45. Squibb, K. S., Cousins, R. J., and Feldman, S. L., 1977. Control of zinc-thionein synthesis in rat liver, Biochem. J. 164: 223.Google Scholar
  46. Thiele, D., Walling, M. J., and Hamer, D., 1986. Mammalian metallothionein is functional in yeast, Science 231: 854.CrossRefGoogle Scholar
  47. Thomas, D. G., Linton, H. J., and Garvey, J. S., 1986. Fluorometric ELISA for the detection and quantification of metallothionein, J. Immunol. Methods 89: 239.CrossRefGoogle Scholar
  48. Thornally, P. J., and Vasak, M., 1985. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals, Biochim. Biophys. Acta 827: 36.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ananda S. Prasad
    • 1
    • 2
    • 3
  1. 1.Department of Medicine, Division of Hematology and OncologyWayne State University School of MedicineUSA
  2. 2.Harper HospitalDetroitUSA
  3. 3.Veterans Administration Medical CenterAllen ParkUSA

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