Sulfur and the Metabolism of Xenobiotics
All living organisms are challenged with the task of obtaining materials from the environment, utilizing those that are nutritious or useful, and excreting those that are not. In some cases the non-nutritious materials, called xenobiotics, that enter the cell have biological effects. Often the effects of xenobiotics are minimal and well tolerated by the cell. In other cases effects can be severe, resulting in impaired cell function, genetic damage or cell death. Therefore, it is essential that cells possess the biochemical means to prevent xenobiotics from reaching toxic concentrations. These mechanisms and the importance of sulfur in them are the subject of this chapter.
KeywordsGlutathione Transferase Sulfate Ester Sulfate Conjugation Mercapturic Acid Organic Hydroperoxide
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