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Application of NMR and Mass Spectrometry to the Study of Drug Hydroxylation

  • C. M. Walls
  • A. Gray
  • R. D. Brownsill
  • C. W. Vose
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Hydroxylation is probably the most common Phase I metabolic pathway for xenobiotics. It is also a pathway readily detectable by MS from the 16 a.m.u. mass shift for the metabolite ions relative to those of the parent compound. However, such information may sometimes be misleading, and MS does not always allow assignment of the site of hydroxylation.

Keywords

Common Phase Additional Hydrogen Atom Monosubstituted Benzene Ring Phenyl Ring Proton Proton Multiplet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • C. M. Walls
    • 1
    • 2
  • A. Gray
    • 1
    • 3
  • R. D. Brownsill
    • 1
    • 3
  • C. W. Vose
    • 1
  1. 1.G.D. Searle & Co. Ltd.High WycombeUK
  2. 2.May & Baker Ltd.Medical Dept.Dagenham, EssexUK
  3. 3.Servier R & DFulrner, SloughUK

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