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The Use of Secondary Ionic Interactions for the Solid-Phase Extraction of Some ‘β-Blocking’ Drugs on C-18 Bonded Silica

  • R. J. Ruane
  • I. D. Wilson
  • G. P. Tomkinson
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

A major advance in the preparation of biological samples for Chromatographic analysis was the introduction of SPE* [which featured strongly in Vol. 16, this series — Ed.]. This methodology involves adsorption of the analyte onto a solid phase (usually a modified silica gel, e.g. C-18 bonded) contained within a disposable cartridge. The compound of interest is then recovered by elution with a suitable solvent. We previously described some unusual and unexpected results obtained with C-18 bonded silica gel SPE cartridges, from two different manufacturers, used for extracting a number of ‘α-blocking’ drugs from plasma [1]. Here we describe further investigations on a wider range of commercially available C-18 cartridges.

Keywords

Silanol Group Imperial Chemical Industry Residual Silanol Group Radiolabelled Compound Disposable Cartridge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ruane, R.J. & Wilson, I.D. (1987) J. Pharm. Biomed. Anal. 5, 723–727.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • R. J. Ruane
    • 1
  • I. D. Wilson
    • 1
  • G. P. Tomkinson
    • 1
  1. 1.Pharmaceuticals DivisionImperial Chemical Industries plcMacclesfield, CheshireUK

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