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Optimization of Capillary GC Conditions for the Analysis of Psychotropic Drugs at Subnanogram Concentrations in Plasma

  • H. M. Hill
  • D. Lessard
  • L. Letarte
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Following a single therapeutic dose many psychotropic drugs are present in plasma at sub-ng concentrations. As a consequence many of the pharmacokinetic parameters of these drugs have been derived from steady-state data using relatively insensitive analytical methodology. In order to gain pharmacokinetic data from a single dose it is necessary to develop a routine assay with high sensitivity and specificity. This requires optimization of Chromatographic and extraction conditions, as now briefly illustrated for two psychotropic agents — thiothixene (TTX), and flurazepam together with its major metabolites desalkylflurazepam (DAF) and hydroxyethylflurazepam (HEF).

Keywords

Pharmacokinetic Parameter Peak Shape Psychotropic Drug Pharmacokinetic Data Extraction Condition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • H. M. Hill
    • 1
  • D. Lessard
    • 1
  • L. Letarte
    • 1
  1. 1.Bioanalytical Research and DevelopmentBio-Research LaboratoriesSennevilleCanada

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