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The Routine Use, and Column-Stability Implications, of Several Column-Switching HPLC Methods for Determining Drugs in Plasma and Urine

  • J. B. Lecaillon
  • C. Souppart
  • J. P. Dubois
  • A. Delacroix
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Several possible configurations can be used for column-switching systems:
  • trace enrichment on a pre-column and automatic back-flush or forward-flush injection of the purified sample on an analytical column;

  • injection of the sample onto one column and automatic selection of a portion of the eluate (heart-cutting) for chromatography on a second column;

  • combination of these two systems: trace enrichment and heart-cutting. These approaches are briefly described for metoprolol, CGP 6140 and oxiracetam.

Keywords

Analytical Column Spiked Sample Metoprolol Tartrate Switching Method Trace Enrichment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • J. B. Lecaillon
    • 1
  • C. Souppart
    • 1
  • J. P. Dubois
    • 1
  • A. Delacroix
    • 2
  1. 1.Biopharmaceutical Research CenterLaboratoires CIBA-GEIGYReuil-MalmaisonFrance
  2. 2.Laboratoire de Chimie IndustrielleConservatoire National des Arts et MétiersParisFrance

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