Abstract
Nifedipine is a calcium channel antagonist used in the treatment of angina and hypertension. It is sensitive, breaking down in daylight to its nitroso derivative and in UV light to its nitropyridine derivative [1]. Thermal decomposition during GC to the nitropyridine led Kondo et al. [2] to develop a method involving direct oxidation of serum with nitrous acid to the light-tolerant nitropyridine (Fig. 1).
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References
Testa, R., Dolfini, E., Reschiotto, C., Secchi, C. & Blondi, P.A. (1979) Il Farmaco 34, 463–473.
Kondo, S., Kuchiki, A., Yamamoto, K., Akimoto, K., Takahashi, K., Awata, N. & Sugimoto, I. (1980) Chem. Pharm. Bull. 28, 1–7.
Dokladalova, J., Tykal, J., Coco, S.J., Durkee, P.E., Quercia, G.T. & Korst, J.J. (1982) J. Chromatog. 231, 451–458.
Tanner, R., Romagnoli, A. & Kramer, W.G. (1986) J. Anal. Toxicol. 10, 250–251.
Tucker, F.A., Minty, P.S.B. & MacGregor, G.A. (1985) J. Chromatog. 342, 193–198.
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© 1988 Springer Science+Business Media New York
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Minty, P.S.B., Tucker, F.A. (1988). Assay Problems with Nifedipine. In: Reid, E., Robinson, J.D., Wilson, I.D. (eds) Bioanalysis of Drugs and Metabolites, Especially Anti-Inflammatory and Cardiovascular. Methodological Surveys in Biochemistry and Analysis, vol 18 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9424-3_19
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DOI: https://doi.org/10.1007/978-1-4757-9424-3_19
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