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Assay Problems with Nifedipine

  • Peter S. B. Minty
  • Felicity A. Tucker
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Nifedipine is a calcium channel antagonist used in the treatment of angina and hypertension. It is sensitive, breaking down in daylight to its nitroso derivative and in UV light to its nitropyridine derivative [1]. Thermal decomposition during GC to the nitropyridine led Kondo et al. [2] to develop a method involving direct oxidation of serum with nitrous acid to the light-tolerant nitropyridine (Fig. 1).

Keywords

Thermal Decomposition Calcium Channel Antagonist Fuse Silica Column Vitreous Silica Varian Vista 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Testa, R., Dolfini, E., Reschiotto, C., Secchi, C. & Blondi, P.A. (1979) Il Farmaco 34, 463–473.Google Scholar
  2. 2.
    Kondo, S., Kuchiki, A., Yamamoto, K., Akimoto, K., Takahashi, K., Awata, N. & Sugimoto, I. (1980) Chem. Pharm. Bull. 28, 1–7.CrossRefGoogle Scholar
  3. 3.
    Dokladalova, J., Tykal, J., Coco, S.J., Durkee, P.E., Quercia, G.T. & Korst, J.J. (1982) J. Chromatog. 231, 451–458.Google Scholar
  4. 4.
    Tanner, R., Romagnoli, A. & Kramer, W.G. (1986) J. Anal. Toxicol. 10, 250–251.CrossRefGoogle Scholar
  5. 5.
    Tucker, F.A., Minty, P.S.B. & MacGregor, G.A. (1985) J. Chromatog. 342, 193–198.Google Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Peter S. B. Minty
    • 1
  • Felicity A. Tucker
    • 1
    • 2
  1. 1.Department of Forensic Medicine and ToxicologyCharing Cross and Westminster Medical SchoolLondonUK
  2. 2.Servier LaboratoriesFulmer, SloughUK

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