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The Assay of Diclofenac and Metabolites: A Review

  • P. H. Degen
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Diclofenac sodium, o-(2,6-dichlorophenyl)aminophenylacetic acid sodium salt, is a well-established potent NSAID*, given in low doses (25–100 mg/day). In man, diclofenac is extensively metabolized mainly by oxidative pathways followed by glucuronide conjugation. A small percentage of the original drug is glucuronidated directly. As diclofenac has a high total clearance, the plasma levels are low, necessitating a specific and very sensitive assay for pharmacokinetic studies.

Keywords

Methyl Iodide Glucuronide Conjugation Enteric Coated Tablet Phenyl Propionic Acid Analytical Method Design 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

NSAITD

non-steroidal anti-inflammatory drug

i.s.

internal standard

ECD

electron-capture detector (similarly NPD, FID)

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • P. H. Degen
    • 1
  1. 1.Research and Development, Pharmaceuticals DivisionCiba-Geigy Ltd.BasleSwitzerland

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