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Analytical Approaches Adopted during the Development of Flurbiprofen

  • A. Bye
  • W. Adams
  • D. Kaiser
Part of the Methodological Surveys in Biochemistry and Analysis book series (MSBA, volume 18 A)

Abstract

Brief mention is made of the assay and stereoselective metabolism of ibuprofen. The NSAID given attention in this article is flurbiprofen, the development of which entailed successive assay methods. That outlined below was used when the number of samples to be assayed was escalating.

Keywords

Propanoic Acid Maximum Daily Dose Drug Development Programme Stereoselective Metabolism Typical HPLC Chromatogram 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviation

NSAID

non-steroidal anti-inflammatory drug

PFB

pentafluorobenzyl

RP

reversed phase

i.s.

internal standard

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References

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    Litowitz, H., Olanoff, L. & Hoppe, C.L. (1984) J. Chromatog. 311, 443–448.Google Scholar
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • A. Bye
    • 1
    • 2
  • W. Adams
    • 1
    • 2
  • D. Kaiser
    • 1
    • 2
  1. 1.Upjohn Ltd.CrawleyUK
  2. 2.The Upjohn CompanyKalamazooUSA

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