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Ramifications of Gaba Receptor Subtypes on Retinal Information Processing

  • Malcolm Slaughter
  • Jian Zhang
  • Ning Tian

Abstract

GABAergic inhibition shapes light responses in both plexiform layers of the vertebrate retina. GABA is contained in a population of horizontal cells and in about one-third of amacrine cells in the amphibian retina. Almost all second and third order neurons have GABA receptors. GABA’s influence is not only diffuse, but also diverse. Pharmacological studies, coupled with amino acid sequence analysis, have identified several subtypes of the GABA receptor, including: the classical GABAa, the GABAb, GABAρ, and GABAc receptors. We have begun investigating the role of these different receptors in information processing in the proximal retina. Although some of our results are preliminary, and our conclusions tentative, it appears that: 1) the GABAa receptor produces a strong, shunting inhibition of amacrine and ganglion cell EPSPs; 2) the GABAb receptor suppresses sustained signals while augmenting transient responses; 3) GABAρ receptors preferentially suppress transient ON responses; and 4) GABAc receptors appear to suppress sustained activity, somewhat similar to the action of GABAb receptors. Overall, GABA can modulate the retinal network through a variety of mechanisms, utilizing different receptor systems, to selectively suppress particular information pathways.

Keywords

Ganglion Cell GABAa Receptor Bipolar Cell Gaba Receptor Amacrine Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Malcolm Slaughter
    • 1
  • Jian Zhang
    • 1
  • Ning Tian
    • 1
  1. 1.Departments of Biophysical Sciences and Ophthalmology, School of MedicineState University of New YorkBuffaloUSA

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