Deformations in the Cytoplasmic Membrane of Escherichia coli Direct the Repair of Peptidoglycan
Turgor pressures of 3.5 Atmospheres in Gram negative bacteria (Stock et al., 1977) and up to 20 Atmospheres in Gram positive bacteria (Mitchell and Moyle, 1956) mean that the weakening of any region of the force-bearing element of the bacterial wall, peptidoglycan, may result in lysis. A repair mechanism to strengthen such regions preferentially may therefore exist. In this communication, a model is proposed in which this mechanism involves local changes in the structure and composition of the cytoplasmic membrane, the requirements of the model are listed and supporting evidence and predictions are discussed.
KeywordsCytoplasmic Membrane Turgor Pressure Phospholipid Composition Micrococcus Luteus Amidase Activity
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