Inhibition of an Autolysin Together with PBP3 Causes the Formation of Bulges: Identification of the Soluble Lytic Tranglycosylase in E. coli as the Specific Target of Bulgecin

  • Markus F. Templin
  • David H. Edwards
  • Joachim-Volker Höltje
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)

Abstract

A coordinated action of murein synthetases and murein hydrolases is assumed to be essential for proper growth of the bacterial cell. A disturbance of this balance, for example by blocking parts of the synthetic pathway turns the hydrolases into autolysins which then cause lysis of the cell (Tomasz, 1979).

Keywords

Crystallization High Performance Liquid Chromatography Catalysis Penicillin Proline 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Markus F. Templin
    • 1
  • David H. Edwards
    • 2
  • Joachim-Volker Höltje
    • 1
  1. 1.Abteilung BiochemieMax-Planck-Institut für EntwicklungsbiologieTübingenGermany
  2. 2.Department of Molecular BiologyUniversity of EdinburghEdinburghScotland

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