Biosynthesis of Peptidoglycan in Gaffkya Homari: Regulation of Transpeptidation by Acceptor Peptide
Gaffkya homari (Aerococcus viridans) contains a system for the biosynthesis of peptidoglycan(PG) that utilizes penicillin-sensitive targets which are not N ∊-(dAla) acceptor transpeptidases. In contrast to cross-linking enzymes from other bacteria, the transpeptidase from this gram-positive organism is essentially insensitive to inhibition by penicillin (Hammes, 1976). Thus, the target of penicillin in G. homari is different from that identified by Tipper and Strominger (1965) for Staphylococcus aureus and Escherichia coli. Because of this difference, an understanding of β-lactam action in this unique organism is of primary interest.
KeywordsHydrolysis Amidated Penicillin Bacillus Streptomyces
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