Identification of the murI and murB Genes Coding for Cytoplasmic Peptidoglycan Synthetases in the 90-Min Region of the E. coli Chromosome

  • Patricia Doublet
  • Jean van Heijenoort
  • Dominique Mengin-Lecreulx*
Part of the Federation of European Microbiological Societies Symposium Series book series (FEMS, volume 65)


The main cytoplasmic precursors of peptidoglycan synthesis are a series of uridine nucleotides which have been previously characterized in Escherichia coli as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-GlcNAc-enolpyruvate, UDP-N-acetylmuramic acid (UDP-MurNAc) and its four peptide derivatives from UDP-MurNAc-L-Ala to UDP-MurNAc-L-Ala-ǒ-D-Glu-meso-DAP-D-Ala-D-Ala. Their sequential formation is catalyzed by a set of eight highly specific enzymes which were earlier studied in detail (Rogers et al., 1980; Mengin-Lecreulx and van Heijenoort, 1985).


Phage Clone Cell Wall Peptidoglycan Peptidoglycan Synthesis WM335 Cell Uridine Nucleotide 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Patricia Doublet
    • 1
  • Jean van Heijenoort
    • 1
  • Dominique Mengin-Lecreulx*
    • 1
  1. 1.URA 1131 du C.N.R.S.Enveloppes bactériennes et peptides Université Paris-SudOrsay CedexFrance

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