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Possible Role of Oxidized Lipids in Atherosclerosis

  • F. A. Kummerow

Abstract

Oxidized sterols, such as cholecalciferol (vitamin D3) and 25-hydroxycholesterol, have been found to act as angiotoxdns when fed to swine or rabbits. These derivatives of oxidized cholesterol increased the frequency of aortic smooth muscle cell death, in­creased mitosis of smooth muscle cells, and increased collagen formation in the thoracic aorta and coronary arteries of swine. Two types of pathology could be developed in the thoracic aorta by continuous or short term feeding of cholecalciferol: one, a diffuse fibroelastic intimai thickening in the thoracic aorta (arterio­sclerosis) with no evidence of lipid deposition by continuous feeding of cholecalciferol or two, an intimal thickening in the thoracic aorta and intimal thickening with foam cells and extra-cellular lipid deposits (atherosclerosis) in the coronary arteries after a short period of supplemental cholecalciferol followed by 3–4 months of supplement-free diets. These two types of arterial damage were identical to that in the plugs of thoracic aorta ob­tained as a by-product of elective coronary bypass surgery.

Keywords

Thoracic Aorta Trans Fatty Acid Beef Tallow Commercial Ration Supplemental Cholecalciferol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • F. A. Kummerow
    • 1
  1. 1.Burnsides Research LaboratoryUniversity of IllinoisUrbanaUSA

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