Advertisement

Abstract

Histoplasmosis is worldwide in distribution but is more prevalent in certain parts of North and Latin America. Histoplasma capsulatum var. capsulatum grows best in soil contaminated with bat or bird droppings. Patients often report exposure to microfoci-contaminated materials. Spores or mycelial fragments are inhaled and cause localized or patchy pneumonitis. Hematogenous dissemination to other tissues commonly follows during the first 2 weeks of infection before specific immunity has developed.

Keywords

Chronic Obstructive Pulmonary Disease Chest Radiograph Histoplasma Capsulatum Bird Dropping Pulmonary Histoplasmosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rippon JW: Histoplasmosis (Histoplasmosis capsulate). In Medical Mycology: The Pathogenic Fungi and the Pathogenic Actinomycetes. Edited by Wonsiewicz M. Philadelphia: WB Saunders; 1988: 381–423.Google Scholar
  2. 2.
    Wheat J: Histoplasmosis: experience during outbreaks in Indianapolis and review of the literature. Medicine 1997, 76: 339–354.PubMedCrossRefGoogle Scholar
  3. 3.
    Brodsky AL, Gregg MB, Kaufman L, Mallison GF: Outbreak of histoplasmosis associated with the 1970 Earth Day activities. Am J Med 1973, 54: 333–342.PubMedCrossRefGoogle Scholar
  4. 4.
    Ozols II, Wheat LJ: Erythema nodosum in an epidemic of histoplasmosis in Indianapolis. Arch Dermatol 1981, 117: 709–712.PubMedCrossRefGoogle Scholar
  5. 5.
    Thornberry DK, Wheat LJ, Brandt KD, Rosenthal J: Histoplasmosis presenting with joint pain and hilar adenopathy: pseudosarcoidosis. Arthritis Rheum 1982, 25: 1396–1402.PubMedCrossRefGoogle Scholar
  6. 6.
    Rosenthal J, Brandt KD, Wheat LJ, Slama TG: Rheumatologic manifestations of histoplasmosis in the recent Indianapolis epidemic. Arthritis Rheum 1983, 26: 1065–1070.PubMedCrossRefGoogle Scholar
  7. 7.
    Wheat LJ, Stein L, Corya BC, et al.: Pericarditis as a manifestation of histoplasmosis during two large urban outbreaks. Medicine 1983 62: 110–119.PubMedCrossRefGoogle Scholar
  8. 8.
    Coss KC, Wheat LJ, Conces DJ Jr, et al.: Esophageal fistula complicating mediastinal histoplasmosis: response to amphotericin B. Am J Med 1987, 83:343–346.PubMedCrossRefGoogle Scholar
  9. 9.
    Wheat LJ, Wass J, Norton J, et al.: Cavitary histoplasmosis occurring during two large urban outbreaks: analysis of clinical, epidemiologic, roentgenographic, and laboratory features. Medicine 1984, 63:201–209.PubMedCrossRefGoogle Scholar
  10. 10.
    Loyd JE, Tillman BF, Atkinson JB, des Prez RM: Mediastinal fibrosis complicating histoplasmosis. Medicine 1988, 67: 295–310.PubMedCrossRefGoogle Scholar
  11. 11.
    Goodwin RA, Nickell JA, des Prez RM: Mediastinal fibrosis complicating healed primary histoplasmosis and tuberculosis. Medicine 1972, 51: 227–246.PubMedCrossRefGoogle Scholar
  12. 12.
    Goodwin RA Jr, Shapiro JL, Thurman GH, et al.: Disseminated histoplasmosis: clinical and pathologic correlations. Medicine 1980, 59:1–33.PubMedCrossRefGoogle Scholar
  13. 13.
    Wheat LJ, Slama TG, Norton JA, et al.: Risk factors for disseminated or fatal histoplasmosis. Ann Intern Med 1982, 96:159–163.PubMedCrossRefGoogle Scholar
  14. 14.
    Sathapatayavongs B, Batteiger BE, Wheat LJ, et al.: Clinical and laboratory features of disseminated histoplasmosis during two large urban outbreaks. Medicine 1983, 62:263–270.PubMedCrossRefGoogle Scholar
  15. 15.
    Wheat LJ, Connolly-Stringfield PA, Baker RL, et al.: Disseminated histoplasmosis in the acquired immune deficiency syndrome: clinical findings, diagnosis and treatment, and review of the literature. Medicine 1990, 69:361–374.PubMedGoogle Scholar
  16. 16.
    Williams B, Fojtasek M, Connolly-Stringfield P, Wheat J: Diagnosis of histoplasmosis by antigen detection during an outbreak in Indianapolis, Ind. Arch Pathol Lab Med 1994, 1 18: 1205–1208.Google Scholar
  17. 17.
    Wheat LJ, Kohler RB, Tewari RP: Diagnosis of disseminated histoplasmosis by detection of Histoplasma capsulatum antigen in serum and urine specimens. N Engl J Med 1986, 314: 83–88.PubMedCrossRefGoogle Scholar
  18. 18.
    Wheat LJ, Connolly-Stringfield P, Blair R. et al.: Histoplasmosis relapse in patients with AIDS: detection using Histoplasma capsulatum variety capsulatum antigen levels. Ann Intern Med 1991, 115:936–941.PubMedCrossRefGoogle Scholar
  19. 19.
    Wheat LJ, French MLV, Kohler RB, et al.: The diagnostic laboratory tests for histoplasmosis: analysis of experience in a large urban outbreak. Ann Intern Med 1982, 97:680–685.PubMedCrossRefGoogle Scholar
  20. 20.
    Wheat J. Hafner R, Korzun AH, et al.: Itraconazole treatment of disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome. Am J Med 1995, 98:336–342.PubMedCrossRefGoogle Scholar
  21. 21.
    Wheat J, MaWhinney S, Hafner R, et al.: Treatment of histoplasmosis with fluconazole in patients with acquired immunodeficiency syndrome. Am J Med 1997, 103:223–232.PubMedCrossRefGoogle Scholar
  22. 22.
    Hecht FM, Wheat J, Korzun AH, et al.: Itraconazole maintenance treatment for histoplasmosis in AIDS: a prospective, multicenter trial. JAcquir Immune Defic Syndr Hum Retrovirol 1997, 16:100–107.PubMedCrossRefGoogle Scholar
  23. 23.
    Wheat J, Hafner R, Wulfson M, et al.: Prevention of relapse of histoplasmosis with itraconazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1993, 118:610–616.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Joseph Wheat

There are no affiliations available

Personalised recommendations