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High-Density Lipoprotein Metabolism

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Atlas of Atherosclerosis

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Abstract

High-density lipoprotein (HDL) cholesterol concentrations are inversely associated with coronary heart disease (CHD) in humans [1,2]. The initial descriptions of this inverse relationship in the early 1950s [3–5] were “rediscovered” in the 1970s [6–9]. The major mechanism proposed for the protective effect of HDL is reverse cholesterol transport, a process in which excess cholesterol from peripheral cells is transported back to the liver for removal from the body [10]. The higher the plasma levels of HDL, the more efficient is the transport to the liver of excess cholesterol from peripheral cells.

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Authors
  1. H. Bryan Brewer Jr.
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Editors and Affiliations

  1. Boston University School of Medicine, Boston, Massachusetts, USA

    Peter W. F. Wilson MD (Professor of Medicine, Director of Laboratories) (Professor of Medicine, Director of Laboratories)

  2. Framingham Heart Study, Framingham, Massachusetts, USA

    Peter W. F. Wilson MD (Professor of Medicine, Director of Laboratories) (Professor of Medicine, Director of Laboratories)

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© 2000 Springer Science+Business Media New York

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Brewer, H.B. (2000). High-Density Lipoprotein Metabolism. In: Wilson, P.W.F. (eds) Atlas of Atherosclerosis. Current Medicine Group, London. https://doi.org/10.1007/978-1-4757-9310-9_7

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  • DOI: https://doi.org/10.1007/978-1-4757-9310-9_7

  • Publisher Name: Current Medicine Group, London

  • Print ISBN: 978-1-4757-9312-3

  • Online ISBN: 978-1-4757-9310-9

  • eBook Packages: Springer Book Archive

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