Advertisement

Structure of the Plasma Lipoproteins

  • Jere P. Segrest
  • David W. Garber
  • G. M. Anantharamaiah

Abstract

Lipoproteins are subcellular-sized particles composed of lipids and proteins held together by noncovalent forces. Their general structure is that of an oil droplet formed from an outer layer of phospholipids, unesterified cholesterol, and proteins, with a core of neutral lipids, predominantly cholesterol ester and triglycerides [1]. Their main function is to transport lipids and lipid-soluble material throughout the body.

Keywords

Cholesteryl Ester Cholesteryl Ester Transfer Protein Plasma Lipoprotein Fatty Acyl Chain Amphipathic Helix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Scanu AM, Landsberger FR, eds: Lipoprotein structure. Ann NY Acad Sci 1980, 348: 1–436.Google Scholar
  2. 2.
    Gotto AM, Pownall HJ, Havel RJ: Introduction to the plasma lipoproteins. Methods Enzymol 1986, 128: 3–41.PubMedCrossRefGoogle Scholar
  3. Segrest JP, Jackson RL, Morrisett JD, et al.: A molecular theory of lipid-protein interactions in the plasma lipoproteins. FEBS Lett 1974, 38:247–253.Google Scholar
  4. Segrest JP, Garber DW, Brouillette CG, et al.: The amphipathic c helix: a multifunctional structural motif in plasma lipoproteins. Adv Protein Chem 1994, 45:303–369.Google Scholar
  5. 5.
    Brown MS, Kovanen PT, Goldstein JL: Receptor mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex. Recent Prog Horm Res 1979, 35: 215–231.PubMedGoogle Scholar
  6. 6.
    Windier E, Chao YS, Havel RJ: Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat. J Biol Chem 1980, 255: 5475–5480.Google Scholar
  7. 7.
    Glomset JA: The plasma lecithin:cholesterol acyltransferase reaction. J Lipid Res 1968, 9: 155–167.PubMedGoogle Scholar
  8. 8.
    Hahn PF: Abolishment of alimentary lipemia following injection of heparin. Science 1943, 98: 19.PubMedCrossRefGoogle Scholar
  9. 9.
    The Expert Panel: Report of the National Cholesterol Education Program Expert Panel on detection, evolution, and treatment of high cholesterol in adults. Arch Intern Med 1988, 148: 36–69.CrossRefGoogle Scholar
  10. 10.
    Scanu AM: Lipoprotein (a) and coronary artery disease. In Plasma, Lipoproteins, and Coronary Artery Disease. Edited by Kriesberg RA, Segrest JP. Cambridge, MA: Blackwell Scientific; 1992: 175–199.Google Scholar
  11. 11.
    Eisenberg S: High density lipoprotein metabolism. J Lipid Res 1984, 25: 1146–1152.Google Scholar
  12. Segrest JP, Jones MK, Mishra VK, et al.: Apolipoprotein B-100 has a pentapartite structure composed of three amphipathic a helical domains alternating with two amphipathic ß strand domains: detection by the computer program LOCATE. Arterioscler Thromb 1994, 14:1674–1685.Google Scholar
  13. 13.
    Fredrickson DS, Levy RI, Lees RS: Fat transport in lipoproteins: an integrated approach to mechanisms and disorders. N Engl J Med 1967, 276: 148–156.PubMedCrossRefGoogle Scholar
  14. 14.
    Grundy SM: Cholesterol and Atherosclerosis: Diagnosis and Treatment New York: Gower Medical Publishing; 1990:2.1–2.25.Google Scholar
  15. 15.
    Lindgren FT: The plasma lipoproteins: historical developments and nomenclature. Ann NY Acad Sci 1980, 348: 1–15.PubMedCrossRefGoogle Scholar
  16. 16.
    Schreiber WE: Medical Aspects of Biochemistry. Boston: Little, Brown & Company; 1984: 57–90.Google Scholar
  17. 17.
    Oberman A, Kreisberg RA, Henkin Y, eds: Principles and Management of Lipid Disorders. Baltimore: Williams & Wilkins; 1992: 87–105.Google Scholar
  18. 18.
    Yeagle P: The Membrane of Cells. Orlando: Academic Press; 1987: 40–61.Google Scholar
  19. 19.
    Stryer L: Biochemistry, edn 3. New York: WH Freeman; 1988: 283–312.Google Scholar
  20. Segrest JP, Jones MK, Klon AE, et al.: A detailed molecular belt model for apolipoprotein A-I in discoidal high density lipoprotein: J Biol Chem 1999, 274:31755–31758.Google Scholar
  21. Kulkarni KR, Garber DW, Marcovina SM, et al.: Quantification of cholesterol in all lipoprotein classes by the VAP-II method. J Lipid Res 1994, 35:159–168.Google Scholar
  22. Cheung MC, Segrest JP, Albers JJ, et al.: Characterization of high density lipoprotein subspecies: structural studies by single vertical spin ultracentrifugation. J Lipid Res 1987, 28:913–929.Google Scholar
  23. Teng B, Thompson GR, Sniderman AD, et al.: Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia. Proc Natl Acad Sci USA 1983, 80:6662–6666.Google Scholar
  24. Austin MA, Breslow JL, Hennekens CH, et al.: Low-density lipoprotein subclass patterns and risk of myocardial infarction. JAMA 1988, 260:1917–1921.Google Scholar
  25. 25.
    Xu S: Apolipoprotein (A) binds to low-density lipoprotein at two distinct sites in lipoprotein(a). Biochemistry 1998, 37: 9284–9294.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Jere P. Segrest
  • David W. Garber
  • G. M. Anantharamaiah

There are no affiliations available

Personalised recommendations