Diabetes Mellitus and Vascular Disease Risk
Diabetes mellitus is a complex, multifactorial disorder that has an overall prevalence of about 5% in the United States. Whereas approximately 90% of diabetics have type II,or non-insulin-dependent diabetes mellitus (NIDDM), the remainder have type I, or insulin-dependent diabetes mellitus (IDDM). The prevalence of diabetes varies greatly among different ethnic groups, with rates as high as 20% in some Asian-Indian and American-Indian populations. These wide variations in prevalence are accounted for mainly by NIDDM. Although the cause or causes of NIDDM are not known, the environment is clearly very important. The molecular basis for IDDM is better defined, but the primary cause remains unclear. Despite the etiologic and pathogenic differences between NIDDM and IDDM, the chronic sequelae of both forms of diabetes are the same, and vascular disease, particularly coronary heart disease (CHD), is the major cause of morbidity and mortality in diabetic patients.
KeywordsCoronary Heart Disease Vascular Calcification Multiple Risk Factor Intervention Trial Amadori Product Bezafibrate Infarction Prevention
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