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Escape of Lentiviruses from Immune Surveillance

  • David L. Huso
  • Opendra Narayan
Part of the Applied Virology Research book series (AVIR, volume 2)

Abstract

Lentiviruses arc nononcogenic retroviruses that cause chronic disease in persistently infected individuals. The viruses are transmitted exogenously and replicate productively in terminally differentiated cells of the immune system. Lentiviruses are transmitted in body fluids and infection often remains inapparent for months or years. Disease begins insidiously and infected individuals eventually develop a chronic multisystemic disease manifest as wasting, immune dysfunction, dyspnea, or neurologic impairment. The viruses are species-specific and members of this group infect a variety of hosts causing unique disease syndromes in each host species. However, the members of the lentivirus group share a remarkable number of biologic, morphologic, and structural features which define this subfamily of viruses (Narayan and Clements, 1987; Haase, 1986).

Keywords

Human Immunodeficiency Virus Sialic Acid Long Terminal Repeat Glycosylation Site Simian Immunodeficiency Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • David L. Huso
    • 1
  • Opendra Narayan
    • 2
  1. 1.Division of Comparative MedicineThe Johns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Division of Comparative Medicine and Department of NeurologyThe Johns Hopkins University School of MedicineBaltimoreUSA

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