New Analogues to Acyclovir with Increased Potency to Herpes Viruses

  • A. Paul Fiddian
Part of the Applied Virology Research book series (AOTP, volume 1)


Acyclovir is highly active in vitro against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2, respectively), moderately active against varicella-zoster virus (VZV) and Eps-tein-Barr virus (EBV), and relatively inactive against cytomegalovirus (CMV). The full extent of the clinical value of acyclovir is still being defined, but we already know much about its efficacy and tolerance in a wide range of herpes virus infections. This has previously been discussed in a number of reviews, including Fiddian (1984), Fiddian et al. (1984), Rees and Fiddian (1985), and most recently Fiddian and Grant (1985).


Herpes Simplex Virus Herpes Zoster Herpes Simplex Virus Infection Oral Acyclovir Intravenous Acyclovir 


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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • A. Paul Fiddian
    • 1
  1. 1.Clinical Antiviral Therapy SectionWellcome Research LaboratoriesBeckenham, KentEngland

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