Production and Quality-Control Testing of Virus Vaccines for Use in Humans

  • J. Furesz
  • D. W. Boucher
  • G. Contreras
Part of the Applied Virology Research book series (AOTP, volume 1)


Vaccination is the best means available for the prevention of viral diseases in humans. This procedure evolved from the use of variolation by the Chinese, centuries before the published work of Jenner, whose first experiment in humans consisted of transferring material from a cowpox lesion of a milkmaid to the arm of a boy (Jenner, 1798). When inoculated with smallpox virus 6 weeks later, the boy was immune to the disease. The global eradication of smallpox from 1967 to 1980 was accomplished with the use of this simply prepared vaccine: vaccinia virus propagated on calf skin. Table 1 describes the highlights in the development of virus vaccines.


Respiratory Syncytial Virus Virus Vaccine Chick Embryo Yellow Fever Oral Poliovirus Vaccine 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • J. Furesz
    • 1
  • D. W. Boucher
    • 1
  • G. Contreras
    • 1
  1. 1.Health Protection Branch, Department of National Health and WelfareBureau of BiologiesOttawaCanada

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