Abstract
The use of radiolabeled antibodies in the detection and treatment of cancer has been in practice since the early 1980’s. Radioimmunoimaging is an in vivo diagnostic technique where a radiolabeled antibody is taken up or bound to an antigen in a target tissue. This allows for non-invasive imaging of the antigen containing tissue, using a gamma camera or a positron emission tomograph (PET) scanner, for subsequent therapy or resection of the tissue if necessary. Radioimmunotherapy is the delivery of a therapeutic quantity of a radioisotope to the same antigen containing tissue to ablate or reduce a primary or metastatic carcinoma. This chapter will cover the basic principles of antibodies, subsequent conjugation with bifunctional chelates and radiolabeling for the purpose of radioimmunoimaging or radioimmunotherapy.
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Schwarz, S.W., Welch, M.J. (1991). Radiolabeled Antibodies: Introduction and Metal Conjugation Techniques. In: Kelly, J.W., Baldwin, T.O. (eds) Applications of Enzyme Biotechnology. Industry-University Cooperative Chemistry Program Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9235-5_1
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