Apoptosis pp 201-212 | Cite as

Regulation of Cell Growth by Transcription Factors, IRF-1 and IRF-2

  • Tadatsugu Taniguchi
  • Hisashi Harada
  • Motoo Kitagawa
  • Nobuyuki Tanaka
  • Nobumasa Watanabe
  • Tohru Kimura
Part of the Pezcoller Foundation Symposia book series (PFSO, volume 5)


Cytokine transmit signals to cell interior, resulting in the activation/repression of the genes critical for cell growth and differentiation. One class of cytokines is the interferons (IFNs), which represent a heterogeneous family of multifunctional cytokines that typically manifest antiviral activity. In fact, viral infections commonly trigger induction of the type-I IFN (IFN-αs and IFN-β) genes in a variety of cells, and these newly produced IFNs can, in turn, activate a set of IFN-inducible genes. IFNs also exhibit anti-proliferative effects on many normal and transformed cells12. In addition, it has been reported that one of the IFN species, IFN-γ, plays a critical role in induced cell death of effector T lymphocyte3.


Oligoadenylate Synthetase Steady State Expression Human Interferon Regulatory Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Tadatsugu Taniguchi
    • 1
  • Hisashi Harada
    • 1
  • Motoo Kitagawa
    • 1
  • Nobuyuki Tanaka
    • 1
  • Nobumasa Watanabe
    • 1
  • Tohru Kimura
    • 1
  1. 1.Institute for Molecular and Cellular BiologyOsaka UniversityOsaka 565Japan

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