Patterns of Resistance in Organisms Causing Gynecologic Infections

  • Haitham Tumah
  • John Woodwell
  • Ashwin Chatwani
  • Allan Truant
  • Thomas Fekete
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 390)


Infections in the female genital tract arise from a variety of sources. In pregnant women, infections tend to occur at parturition—especially after cesarean section. In the non-pregnant adult, some of these infections are spontaneous or the sequela of sexually transmitted disease. Others are related to anatomical problems with the genitals or to surgical processes. Variations in the distribution and susceptibility patterns of community or hospital acquired infections have led to changes in the use of antimicrobials for ambulatory and hospitalized patients. We report on the susceptibility to a number of antibiotics of a variety of organisms isolated from endocervical or deeper cultures of women with acute pelvic inflammatory disease (PID) or endomyometritis. We also review the information regarding trends in antimicrobial susceptibility for bacteria involved with female genital infections.


Bacterial Vaginosis Chlamydia Trachomatis Pelvic Inflammatory Disease Neisseria Gonorrhoeae Female Genital Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    R.L. Sweet and R.S. Gibbs. 1985. pp. 127–141. Infectious diseases of the female genital tract. Williams and Wilkins, Baltimore, Md.Google Scholar
  2. 2.
    Centers for Disease Control and Prevention. 1993. 1993 Sexually transmitted diseases treatment guidelines. Morbid. Mortal. Weekly Rep. 42 RR-14: 50–66.Google Scholar
  3. 3.
    G.W. Counts. 1988. Cefoxitin: its role in treatment and prophylaxis of obstetric and gynecologic infections. Rev. Infect. Dis. 10: 76–91.Google Scholar
  4. 4.
    R.L. Sweet and W.J. Ledger. 1979. Cefoxitin: Single-agent treatment of mixed aerobic-anaerobic pelvic infections. Obstet. and Gynec. 54: 193–198.Google Scholar
  5. 5.
    M.B. Hasselquist and S. Hillier. 1991. Susceptibility of upper-genital tract isolates from women with pelvic inflammatory disease to ampicillin, cefpodoxime, metronidazole, and doxycycline. Sex. Trans. Dis. 18: 146–149.Google Scholar
  6. 6.
    M.L. Maccato, S. Faro, M.G. Martens, and H.A. Hammill. 1991. Ciprofloxacin versus gentamicin/clindamycin for postpartum endometritis. J. Reprod. Med. 36: 857–861.Google Scholar
  7. 7.
    K. Rosene, D.A. Eschenbach, L.S.. Tompkins, G.E. Kenny, and H. Watkins. 1986. Polymicrobial early postpartum endometritis with facultative and anaerobic bacteria, genital mycoplasmas, and Chlamydia trachomatis: treatment with piperacillin or cefoxitin. J. Infect. Dis. 153: 1028–1045.Google Scholar
  8. 8.
    R.L. Sweet, M.O. Robbie, M. Ohm-Smith, and W.K. Hadley. 1983. Comparative study of piperacillin versus cefoxitin in the treatment of obstetric and gynecologic infections. Am. J. Obstet. Gynecol. 145: 342–349.Google Scholar
  9. 9.
    J.G. Pastorek and C.V. Sanders, Jr. 1991. Antibiotic therapy for postcesarean endomyometritis. Rev. Infect. Dis. 13 (Suppl 9): S752–757.PubMedCrossRefGoogle Scholar
  10. 10.
    P. Summanen. 1993. Recent taxonomic changes for anaerobic gram-positive and selected gram-negative organisms. Rev. Infect. Dis. 1993 (Suppl 4): S168–174.CrossRefGoogle Scholar
  11. 11.
    W.R. Crombleholme, J. Schachter, M. Ohm-Smith, J. Luft, R. Whidden, and R.L. Sweet. 1989. Efficacy of single-agent therapy for the treatment of acute pelvic infalmmatory disease with ciprofloxacin. Am J. Med. 87 (Suppl 5A): 142S - 147S.PubMedCrossRefGoogle Scholar
  12. 12.
    T. Fekete. 1993. Antimicrobial susceptibility testing of Neisseria gonorrhoeae and implications for epidemiology and treatment. Clin. Microbiol. Rev. 6: 22–33.Google Scholar
  13. 13.
    J.H. Tiedemann, J.F. Hackney, and E.V. Price. 1965. Acute gonorrheal urethritis in men: treatment with spectinomycin sulfate. JAMA 191: 101–103.CrossRefGoogle Scholar
  14. 14.
    J.M. Ehret and F.N. Judson. 1988. Susceptibility testing of Chlamydia trachomatis: from eggs to monoclonal antibodies. Antimicrob. Agents Chemother. 32: 129–599.Google Scholar
  15. 15.
    L. Slaney, H. Chubb, A. Ronald, and R. Brunham. 1990. In-vitro activity of azithromycin, erythromycin, ciprofloxacin and norfloxacin against Neisseria gonorrhoeae, Haemophilus ducreyi, and Chlamydia trachomatis. J. Antimicro. Chemother. 25 (Suppl A): 1–5.CrossRefGoogle Scholar
  16. 16.
    R.B. Jones, B. Van der Pol, D.H. Martin, and M.K. Shepard. 1990. Partial characterization of Chlamydia trachomatis isolates resistant to multiple antibiotics. J. Infect. Dis. 162: 1309–1315.Google Scholar
  17. 17.
    R.N. Jones. 1989. Cefmetazole (CS-1170), a “new” cephamycin with a decade of clinical experience. Diagn. Microbiol. Infect. Dis. 12: 367–379.Google Scholar
  18. 18.
    R.C. Brunham, B. Binns, F. Guijon, D. Danforth, M.L. Kosseim, R. Rand, J. McDowell, and E. Rayner. 1988. Etiology and outcome of pelvic inflammatory disease. J. Infect. Dis. 158: 510–517.Google Scholar
  19. 19.
    C.K. Walker, J.G. Kahn, A.E. Washington, H.B. Peterson, and R.L. Sweet. 1993. Pelvic inflammatory disease: metaanalysis of antimicrobial regimen efficacy. J. Infect. Dis. 168: 969–78.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Haitham Tumah
    • 1
  • John Woodwell
    • 1
  • Ashwin Chatwani
    • 1
  • Allan Truant
    • 1
  • Thomas Fekete
    • 1
  1. 1.Temple University Health Sciences CenterPhiladelphiaUSA

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