In Vivo Assays for Angiogenesis
Angiogenesis, the formation of new blood vessels, is an important element of a large number of normal and disease processes. The most dramatic physiologically normal angiogenesis occurs during the development of the placental and embryonic vasculature. The most striking disease-associated angiogenesis is seen in the growth of solid tumors. But angiogenesis also accompanies normal processes such as the cyclical changes of the endometrium and the hair follicle, and the reparative events involved in the healing of wounds. The range of angiogenesis-associated disease processes is even broader: Angiogenesis is seen in sites of immunological activity ranging from autoimmune diseases to inflammation; it is almost universally associated with ocular diseases and injury, it is prominent in psoriasis and scleroderma, and it is a hallmark of granulomatous lesions. Studies of angiogenesis and its inhibition are therefore an integral part of numerous research programs both in academic institutions and in pharmaceutical firms interested in the development of angiogenic or anti-angiogenic strategies.
KeywordsAlginate Bead Corneal Neovascularization Divarication Site Sodium Alginate Bead Embryonic Vasculature
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