Abstract
Group B Streptococcus is a major pathogen in hospital nurseries in the United States affecting 10,000 neonates each year with the mortality rate of approximately 15%. GBS pneumonia, often called early onset disease, presents with signs of sepsis, granulocytopenia, and respiratory distress and is characterized by pulmonary hypertension and increased vascular permeability and proteinaceous pulmonary edema. After treatment with antibiotic, the neonate is cured of the infection but the symptoms of early onset disease persist which suggests the involvement of an extracellular toxin similar to gram-negative endotoxin shock. These observations led us to analyze both bacteria and media components which could be responsible for the induction of respiratory distress in the neonate.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
C.G. Hellerqvist, J. Rojas, R.S. Green, S. Sell, H. Sundell and M.T. Stahlman. “Studies on Group B 13-Hemolytic Streptococcus. I. Isolation and Partial Characterization of an Extracellular Toxin,” Pediatric Res. 15: 892 (1981).
C.G. Hellerqvist, H. Sundell and P. Gettins. “Molecular Basis for Group B I3-Hemolytic Streptococcal Disease,” Proc. Natl. Acad. Sci., U.S.A. 84: 51 (1987).
B. Russell, R. Pappas, J. Brandt, H. Sundell, C.G. Hellerqvist. “Use of Polyclonal Rabbit Anti-GBS Toxin IgG for Localization of a Possible Toxin Binding Site in Sheep Lung Tissue,” Annual Meeting of the Society for Complex Carbohydrates Glycoconj. J. 5: 298 (1988).
H.W. Sundell, W. Fish, K. Sandberg, K.E. Edberg, R.S. Pappas and C.G. Hellerqvist.: Lung Injury by Streptococcal Toxins,: Vanderbilt University Press (1989).
C.J. Baker, F. Bamett, R.C. Gordon, and H.D. Yone.:Suppurative Meningitis due to Streptococci of Lancefield Group B: A Study of 33 Infants,: J. Pediatr. 82: 724 (1973).
C.G. Hellerqvist. :Therapeutic Agent and Method of Inhibiting Vascularization of Tumors,: U.S.Patent 5,010,062 - April 23, 1991 - World Patent Pending.
C.G. Hellerqvist, G.B. Thurman, D.L. Page, Yue-Fen Wang, B.A. Russell, C.A. Montgomery and H.W. Sundell. :Anti-tumor Effects of GBS Toxin: A Polysaccharide Exotoxin from Group B 13-Hemolytic Streptococcus : CancerResearch and Clinical Oncology (1993) (In Press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Hellerqvist, C.G. et al. (1994). Anti-Tumor Effects of GBS Toxin are Caused by Induction of a Targeted Inflammatory Reaction. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_29
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9188-4_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9190-7
Online ISBN: 978-1-4757-9188-4
eBook Packages: Springer Book Archive