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Therapeutic Angiogenesis in Surgery and Oncology

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Book cover Angiogenesis

Part of the book series: NATO ASI Series ((NSSA,volume 263))

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Abstract

The aim of this presentation is to demonstrate the pathological importance of microenvironmental tissue hypoxia and to elucidate a general treatment concept for this situation which we have termed therapeutic angiogenesis 1. Hypoxia not only represents an insufficient oxygen supply for the cells of a given tissue area but is also regarded as an indicator for their metabolic deprivation and the concomitant accumulation of waste products. Therapeutic angiogenesis applied either with clinically established methods or using novel ways, which are the objectives of laboratory research and clinical trials at present, or in so far hypothetical forms, should lead to an expansion of the functional microvascular space resulting in an increased nutritive blood flow. Thus microregional oxygen availability should be elevated and directly counteract local tissue hypoxia. The problems of nutritional deprivation and waste product accumulation are also treated by therapeutic angiogenesis.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University of Mainz Medical Center, 6500, Mainz, Germany

    Michael Höckel, Karlheinz Schlenger, Renate Frischmann-Berger & Sabine Berger

  2. Institute of Physiology and Pathophysiology, University of Mainz Medical Center, 6500, Mainz, Germany

    Peter Vaupel

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  1. Michael Höckel
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  2. Karlheinz Schlenger
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  3. Renate Frischmann-Berger
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  4. Sabine Berger
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Editors and Affiliations

  1. University of Patras Medical School, Patras, Greece

    Michael E. Maragoudakis

  2. University of Torino Medical School, Torino, Italy

    Pietro M. Gullino

  3. University of Wisconsin Medical School, Milwaukee, Wisconsin, USA

    Peter I. Lelkes

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Höckel, M., Schlenger, K., Frischmann-Berger, R., Berger, S., Vaupel, P. (1994). Therapeutic Angiogenesis in Surgery and Oncology. In: Maragoudakis, M.E., Gullino, P.M., Lelkes, P.I. (eds) Angiogenesis. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9188-4_22

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