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Angiogenesis pp 193-207 | Cite as

Therapeutic Angiogenesis in Surgery and Oncology

  • Michael Höckel
  • Karlheinz Schlenger
  • Renate Frischmann-Berger
  • Sabine Berger
  • Peter Vaupel
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

The aim of this presentation is to demonstrate the pathological importance of microenvironmental tissue hypoxia and to elucidate a general treatment concept for this situation which we have termed therapeutic angiogenesis 1. Hypoxia not only represents an insufficient oxygen supply for the cells of a given tissue area but is also regarded as an indicator for their metabolic deprivation and the concomitant accumulation of waste products. Therapeutic angiogenesis applied either with clinically established methods or using novel ways, which are the objectives of laboratory research and clinical trials at present, or in so far hypothetical forms, should lead to an expansion of the functional microvascular space resulting in an increased nutritive blood flow. Thus microregional oxygen availability should be elevated and directly counteract local tissue hypoxia. The problems of nutritional deprivation and waste product accumulation are also treated by therapeutic angiogenesis.

Keywords

Muscle Flap Therapeutic Angiogenesis Pelvic Wall Surgical Debulking Chronic Venous Insufficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Michael Höckel
    • 1
  • Karlheinz Schlenger
    • 1
  • Renate Frischmann-Berger
    • 1
  • Sabine Berger
    • 1
  • Peter Vaupel
    • 2
  1. 1.Department of Obstetrics and GynecologyUniversity of Mainz Medical CenterMainzGermany
  2. 2.Institute of Physiology and PathophysiologyUniversity of Mainz Medical CenterMainzGermany

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