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Angiogenesis pp 119-123 | Cite as

A Novel Laminin Domain Involved in Adhesion of Endothelial Cells

  • Aristidis Charonis
  • Nitsa Koliakos
  • George Koliakos
  • Gregg Fields
  • Lorrel Regger
  • Carrie Lynch
  • Mark Spreeman
  • Anne Hunter
  • Howard Higson
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

Endothelial cells interact with various cell types and with extracellular matrices; both types of interactions are important for their functional integrity. Most endothelial cells are underlined by a basement membrane, which is a very specialized form of extracellular matrix. It contains several macromolecules present exclusively in it and absent from any other extracellular matrix compartment. These macromolecules are: type IV collagen, laminin, entactin/nidogen, perlekan(a form of heparan sulfate proteoglycan), chondroitin sulfate proteoglycan. Most of them exist in various isoforms which interact in complicated ways to form the heteropolymeric and heterogeneous structure which is defined as basement membranel.

Keywords

Control Peptide Chondroitin Sulfate Proteoglycan Endothelial Cell Motility Outer Globule Peptide AC15 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Aristidis Charonis
    • 1
  • Nitsa Koliakos
    • 1
  • George Koliakos
    • 1
  • Gregg Fields
    • 1
  • Lorrel Regger
    • 1
  • Carrie Lynch
    • 1
  • Mark Spreeman
    • 1
  • Anne Hunter
    • 1
  • Howard Higson
    • 1
  1. 1.Department of Lab. Med. PathologyUniversity of Minnesota Medical SchoolMinneapolisUSA

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