Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins
Diabetic retinopathy is characterized by microaneyrisms derived from vessels which have selectively lost their pericytes and demonstrate focal proliferation of endothelial cells. The proliferation of retinal endothelial cells and the pericytic degeneration followed by replacement with pericytic “ghosts” is an almost invariable and early feature of diabetic retinopathy 1.
KeywordsDiabetic Retinopathy Glomerular Basement Membrane Aldose Reductase Inhibitor Retinal Endothelial Cell Retinal Cell Type
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