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Angiogenesis pp 111-118 | Cite as

Altered Proliferation of Retinal Microvascular Cells in Response to Non-Enzymatic Glycosylated Matrix Proteins

  • Theodosia A. Kalfa
  • Mary E. Gerritsen
  • Effie C. Tsilibary
Chapter
Part of the NATO ASI Series book series (NSSA, volume 263)

Abstract

Diabetic retinopathy is characterized by microaneyrisms derived from vessels which have selectively lost their pericytes and demonstrate focal proliferation of endothelial cells. The proliferation of retinal endothelial cells and the pericytic degeneration followed by replacement with pericytic “ghosts” is an almost invariable and early feature of diabetic retinopathy 1.

Keywords

Diabetic Retinopathy Glomerular Basement Membrane Aldose Reductase Inhibitor Retinal Endothelial Cell Retinal Cell Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D.G. Cogan, D. Toussaint, and T. Kuwaraba, Retinal Vascular Patterns: Diabetic Retinopathy, Arch Opthalmol. 66: 366–378 (1961).CrossRefGoogle Scholar
  2. 2.
    M. Brownlee, A. Cerami, and H. Vlassara, Advanced products of nonenzymatic glycosylation and the pathogenesis of diabetic vascular disease, Diabetes Metab Rev. 4: 437–51 (1988).PubMedCrossRefGoogle Scholar
  3. 3.
    D.A. Greene, S.A. Lattimer, and A.A. Sima, Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications, N Engl J Med. 316: 599–606 (1987).PubMedCrossRefGoogle Scholar
  4. 4.
    T.S. Kern and R.L. Engerman, Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor, Invest Ophthalmol Vis Sci. 32: 3175–7 (1991).PubMedGoogle Scholar
  5. 5.
    T.S. Kern and R.L. Engerman, Aldose reductase inhibition fails to prevent retinopathy in diabetic and galactosemic dogs, Diabetes. 42: 820–825 (1993).PubMedCrossRefGoogle Scholar
  6. 6.
    W.J. Robison, M. Nagata, N. Laver, T.C. Hohman, and J.H. Kinoshita, Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor, Invest Ophthalmol Vis Sci. 30: 2285–92 (1989).PubMedGoogle Scholar
  7. 7.
    Sorbinil Retinopathy Trial Research Group, A randomized trial of sorbinil, an aldose reductase inhibitor, in diabetic retinopathy, Arch Ophthalmol. 108: 1234–44 (1990).Google Scholar
  8. 8.
    V.M. Monnier, V. Vishwanath, K.E. Frank, C.A. Elmets, P. Dauchot, and R.R. Kohn, Relation between complications of type I diabetes mellitus and collagen-linked fluorescence, N Engl J Med. 314: 403–8 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    H.K. Kleinman, M.L. McGarvey, L.A. Liotta, P.G. Robey, K. Tryggvason, and G.R. Martin, Isolation and characterization of type IV procollagen, laminin and heparan sulfate proteoglycan from the EHS sarcoma, Biochemistry. 21: 6188–6193 (1982).PubMedCrossRefGoogle Scholar
  10. 10.
    R. Timpl, H. Rhode, P. Gehron-Robey, S.I. Rennard, J.-M. Foidart, and G.R. Martin, Laminin: a glycoprotein from basement membranes, J. Biol. Chem. 254: 9933–9937 (1979).PubMedGoogle Scholar
  11. 11.
    C.S. Haitoglou, E.C. Tsilibary, M. Brownlee, and A.S. Charonis, Altered cellular interactions between endothelial cells and nonenzymatically glucosylated laminin/type IV collagen, J Biol Chem. 267: 12404–7 (1992).PubMedGoogle Scholar
  12. 12.
    A. Capetandes and M.E. Gerritsen, Simplified methods for consistent and selective culture of bovine retinal endothelial cells and pericytes, Invest Ophthalmol Vis Sci. 31: 1738–44 (1990).PubMedGoogle Scholar
  13. 13.
    W.B. Jakoby and I.H. Pastan.“Cell Culture,”Academic Press, INC, San Diego, CA (1979).Google Scholar
  14. 14.
    W. Li, S. Shen, M. Khatami, and J.H. Rockey, Stimulation of retinal capillary pericyte protein and collagen synthesis in culture by high-glucose concentration, Diabetes. 33: 785–9 (1984).PubMedCrossRefGoogle Scholar
  15. 15.
    N. Ashton, Pathogenesis of diabetic retinopathy, in “Diabetic Retinopathy,”H.L. Little, R.L. Jack, A. Patz, and P.H. Forsham, Thieme-Stratton Inc, New York (1983).Google Scholar
  16. 16.
    M.P. Cohen, E. Urdanivia, M. Surma, and V.Y. Wu, Increased glycosylation of glomerular basement membrane collagen in diabetes, Biochem Biophys Res Commun. 95: 765–9 (1980).PubMedCrossRefGoogle Scholar
  17. 17.
    M.P. Cohen, E. Urdanivia, and V.Y. Wu, Nonenzymatic glycosylation of glomerular basement membrane, Renal Physiol. 4: 90–5 (1981).PubMedGoogle Scholar
  18. 18.
    A.J. Perejda and J. Uitto, Nonenzymatic glycosylation of collagen and other proteins: relationship to development of diabetic complications, Coll Relat Res. 2: 818 (1982).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Theodosia A. Kalfa
    • 1
  • Mary E. Gerritsen
    • 2
  • Effie C. Tsilibary
    • 1
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Minnesota Medical SchoolUSA
  2. 2.Miles LaboratoriesWest HavenUSA

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