Angiogenesis pp 97-101 | Cite as

Reactivation of Metalloproteinase-Inhibitor Complex by a Low Molecular Mass Angiogenic Factor

  • B. Mclaughlin
  • J. B. Weiss
Part of the NATO ASI Series book series (NSSA, volume 263)


It has now become widely accepted that there is involvement of neutral matrix metalloproteinases (MMPs), in angiogenesis. The initial event in angiogenesis was described by Ausprunk in 1979 as dissolution or degradation of the capillary basement membrane, which it was suggested would permit migration of microvessel endothelial cells through the dense collagenous stroma, enabling penetration of new microvessels. The control of matrix degradation via metalloproteinase activity must therefore be regarded as an important step in the promotion of angiogenesis.


High Performance Liquid Chromatography Diethyl Amino Ethyl Collagen Type Versus Microvessel Endothelial Cell Capillary Basement Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • B. Mclaughlin
    • 1
  • J. B. Weiss
    • 1
  1. 1.Wolfson Angiogenesis Unit Department of RheumatologyManchester University, Hope HospitalManchesterEngland

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