The Proliferative Effect of Substance P on Capillary Endothelial Cells is Mediated by Nitric Oxide

  • M. Ziche
  • L. Morbidelli
  • L. Mantelli
  • E. Masini
  • F. Ledda
  • H. J. Granger
  • C. A. Maggi
Part of the NATO ASI Series book series (NSSA, volume 263)


Under physiological circumstances the ability of a given tissue to produce a neovascular response is under strict control, i.e. the balance between factors and events favoring or interfering with neovascular growth is in equilibrium. Modification of the normal cell/cell and cell/matrix boundaries, which maintain tubular morphology of the endothelium at the postcapillary level, is a prerequisite for capillary endothelial cell mobilization and proliferation to constitute a neovascular response.


Nitric Oxide Nitric Oxide Thymidine Incorporation Guanylate Cyclase Capillary Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • M. Ziche
    • 1
  • L. Morbidelli
    • 1
  • L. Mantelli
    • 1
  • E. Masini
    • 1
  • F. Ledda
    • 1
  • H. J. Granger
    • 2
  • C. A. Maggi
    • 3
  1. 1.Dept. of PharmacologyUniversity of FlorenceFlorenceItaly
  2. 2.Dept of Medical PhysiologyTexas A&M UniversityCollege StationUSA
  3. 3.Pharmacology Dept.A. Menarini PharmaceuticalsFlorenceItaly

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