The Rat and the Rabbit Cornea Assay

  • Lucia Morbidelli
  • Marina Ziche
Part of the NATO ASI Series book series (NSSA, volume 298)


In order to develop angiogenic and antiangiogenic strategies, there are concerted efforts to provide animal model for more quantitative analysis of in vivo angiogenesis. In vivo techniques consist in the rat and rabbit cornea assay, the sponge implant assay, the fibrin clots, sodium alginate beads and matrigel plugs and the chick embryo chorioallantoic membrane. In this chapter we will discuss on the avascular cornea assay and the advantages and divadvantages in the rat and the rabbits, the two animal species most used.


Angiogenic Response Vascular Endothelial Cell Growth Factor Corneal Neovascularization Rabbit Cornea Matrigel Plug 


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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Lucia Morbidelli
    • 1
  • Marina Ziche
    • 1
  1. 1.Dept. PharmacologyUniversity of FlorenceFlorenceItaly

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