Scatter Factor as a Mediator of Tumor Angiogenesis
Scatter factor (SF) (also known as hepatocyte growth factor (HGF)) is an invasogenic and angiogenic cytokine that has been implicated in diverse biologic processes, including organ regeneration, embryogenesis, wound healing, and carcinogenesis (reviewed in Rosen et al., 1994c). SF-induced biologic responses are mediated through the canonical SF receptor, a transmembrane protein tyrosine kinase encoded by a proto-oncogene (c-Met) (Bottaro et al., 1991; Gonzatti-Haces et al., 1988). Two years ago, at the NATO Advanced Study Institute conference on “Molecular, Cellular, and Clinical Aspects of Angiogenesis”, we presented our studies on the ability of SF to induce an angiogenic phenotype in cultured vascular endothelial cells and to induce new blood vessel formation in several in vivo assays of angiogenesis, including the mouse Matrigel assay and the rat corneal neovascularization assay. We also presented data suggesting a prominent role for SF and the c-Met receptor in the pathogenesis of AIDS-related Kaposi’s sarcoma, a tumor associated with prominent components of endothelial cell proliferation and angiogenesis. These studies are reviewed in two chapters in the Nato Series A: Life Sciences Vol. 285 (see Rosen and Goldberg, 1996; Rosen et al., 1996b). Additional information can be found in the original references (see Rosen et al., 1991a and b; Grant et al., 1993; Naidu et al., 1994; Rosen and Goldberg, 1995).
KeywordsHepatocyte Growth Factor Tumor Angiogenesis Transitional Cell Carcinoma Scatter Factor Infiltrate Ductal Carcinoma
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