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Angiogenesis pp 349-353 | Cite as

Cytokines and Growth Factors. Early Gene Expression During Angiogenic Stimuli

  • David BenEzra
  • Shai Yarkoni
  • Genia Maftzir
  • Haya Loberboum-Galski
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

From accumulating experimental observations, it has become evident that angiogenesis — the sprouting of new blood vessels from other mature vessels — can be induced by a myriad of angiogenic factors1,2. Despite their potential roles in initiating the process, these factors, most probably, influence a single (or a few) events within a very complex cascade of pathways which finally lead to angiogenesis as observed in vivo1.

Keywords

Vascular Endothelial Growth Factor Angiogenic Factor Human Albumin Vascular Endothelial Growth Factor mRNA mRNA Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. BenEzra D. Neovasculogenic ability of prostaglandins, growth factors and synthetic chemoattractants. Am. J. Ophthalmol. 86:455–461, 1978.PubMedGoogle Scholar
  2. Folkman J, Klagsbrun M. Angiogenic factors. Science. 235: 442–447, 1987.PubMedCrossRefGoogle Scholar
  3. BenEzra, D. Neovasculogenesis. Triggering factors and possible mechanisms. Survey Ophthalmol. 24:167–176, 1979.CrossRefGoogle Scholar
  4. BenEzra, D., Hemo, I., and Maftzir, G. In vivo angiogenic activity of interleukins. Arch. Ophthalmol. 108:573–576, 1990.PubMedCrossRefGoogle Scholar
  5. BenEzra, D., Griffin, B.W., Maftzir, G. and Aharonov, O. Thrombospondin enhances in vivo angiogenesis induced by bFGF or lipopolysaccharide. Invest. Ophthalmol. Vis. Sei. 34:3601–3608, 1993.Google Scholar
  6. BenEzra, D. The corneal model for the study of angiogenesis. Angiogenesis: Molecular Biology, Clinical Aspects Maragoudakis ME (Ed.) Plenum Press, New York, 1994 pp. 315–320.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David BenEzra
    • 1
  • Shai Yarkoni
    • 2
  • Genia Maftzir
    • 1
  • Haya Loberboum-Galski
    • 2
  1. 1.Department of OphthalmologyHadassah Hebrew University Hospital and Medical SchoolJerusalemIsrael
  2. 2.Department of Molecular BiologyHadassah Hebrew University Hospital and Medical SchoolJerusalemIsrael

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