Angiogenesis pp 337-347 | Cite as

Tumour Angiogenesis and Metastasis: The Regulatory Role of Hyaluronan and Its Degradation Products

  • D. C. West
  • D. M. Shaw
  • M. Joyce
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Hyaluronan (HA, previously termed hyaluronic acid) is a high molecular weight glycosaminoglycan, a linear polysaccharide made up of a repeating disaccharide unit [D-glucuronic acid (l-β-3) N-acetyl-D-glucosamine] linked by l-β-4 glycosidic bonds. It is present in the extracellular matrix of most animal tissues and this ubiquitous distribution, its capacity to bind large amounts of water, and its simple structure led to the general belief that it was essentially a structural, or space filling, molecule. However, in the last ten years HA has been shown to profoundly influence cell behaviour. Transient increases in tissue HA levels coincide with rapid cell proliferation and migration, during embryonic development and the regeneration and remodelling of adult tissues. Localized accumulation has been reported in association with tissue damage, organ rejection and many inflammatory diseases, notably psoriasis and scleroderma, and it is a major component of many tumours(Laurent and Fraser, 1992; Knudson et al., 1989). The temporal and spatial distribution of HA during embryogenesis, and tissue remodelling, suggests that the sythesis and degradation of HA plays an important regulatory role in these processes, and certain pathological conditions such as tumour growth.

Keywords

Migration Arthritis Polysaccharide Sponge Psoriasis 

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References

  1. Arnold, F., Jia, C.Y., He, CF., Cherry, G.W., Carbow, B., Meyer-Ingold, W., Bader, D. and West, D.C., 1995, Hyaluronan, heterogeneity and healing: The effects of ultra-pure hyaluronan of defined molecular size on the repair of full thickness pig skin wounds. Wound Rep Reg. 3: 10–21.CrossRefGoogle Scholar
  2. Balazs, E.A., and Darzynkiewcz, Z., 1973, The effect of hyaluronic acid on fibroblasts, mononuclear phagocytes and lymphocytes, in: Biology of the fibroblast (E. Kulonen, and J. Pikkarainen, eds), pp. 237–52, Acad Press, New YorkGoogle Scholar
  3. Banerjee, S.D. and Toole, B.P., 1992, Hyaluronan-binding protein in endothelial morphogenesis. J Cell Biol. 119:643–52.PubMedCrossRefGoogle Scholar
  4. Bennett, C.F., Condon, T.P., Grimm, S., Chan, H., and Chiang M-Y., 1994, Inhibition of endothelial cell adhesion molecule expression with antisense oligonucleotides. J. Immunol. 152: 3530–40.PubMedGoogle Scholar
  5. Dvorak, H.F., Harvey, S., Estralla, P., Brown, L.F., McDonagh, J., and Dvorak, A.M., 1987, Fibrin containing gels induce angiogenesis, Lab Invest. 57: 673–86.PubMedGoogle Scholar
  6. Feinberg, R.N. and Beebe, D.C., 1983, Hyaluronate in vasculogenesis, Science. 220: 1177–1179.PubMedCrossRefGoogle Scholar
  7. Folkman, J., 1990, What is the evidence that tumors are angiogenesis dependent?, J. Natl. Cancer. Inst. 82: 4–6.PubMedCrossRefGoogle Scholar
  8. Folkman, J., 1995, Angiogenesis in cancer, vascular, rheumatoid and other disease, Nature Medicine. 1:27–31.PubMedCrossRefGoogle Scholar
  9. Fournier, N. and Doillon, C.J., 1992, In vitro angiogenesis in fibrin matrices containing fibronectin or hyaluronic acid. Cell Biol Int Reports. 16: 1251–63.CrossRefGoogle Scholar
  10. Hart, I.R. and Saini, A., 1992, Biology of tumour metastasis, Lancet. 339: 1453–7.PubMedCrossRefGoogle Scholar
  11. Hirata, S., Akamarsu, T., Matsubara, T., Mizuno, K. and Ishikawa, H., 1993, Arthritis & Rheum. 36:S247.CrossRefGoogle Scholar
  12. Kinsella, A.R., Lepts, G.C., Hill, C.L. and Jones, M., 1994, Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines. Clin Exp Metastasis. 12: 335–342PubMedCrossRefGoogle Scholar
  13. Knudson, W., Biswas, C, Li, X.-Q., Nemec, R.E. and Toole, B.P., 1989, The role and regulation of tumour-associated hyaluronan. in: The Biology of Hyaluronan, Ciba Foundation Symposium 143 (D. Evered, and J. Whelan, eds), pp. 150–169, John Wiley and Sons, ChichesterGoogle Scholar
  14. Kumar, S., West, D.C., Ponting, J. and Gattamaneni, H.R., 1989, Sera of children with renal tumour contain low molecular mass hyaluronic acid. Int. J. Cancer. 44: 445–8.PubMedCrossRefGoogle Scholar
  15. Lees, V.C., Fan, T-P.D. and West, D.C., 1995, Angiogenesis in a delayed revascularization model is accelerated by angiogenic oligosaccharides of hyaluronan, Lab Invest. 73:259–266.PubMedGoogle Scholar
  16. Liu, D., Pearlman, E., Diaconu, E., Guo, K., Mori, H., Haqqi, T., Markowitz, S., Willson, J., and Sy, M-S., 1996, Expression of hyaluronidase by tumor cells induces angiogenesis in vivo. Proc. Natl. Acad. Sei. U.S.A. 93: 7832–7837.CrossRefGoogle Scholar
  17. Locci, P., Marinucci, L., Lilli, C, Martinese, D. and Becchetti, E., 1995, Transforming growth factor beta 1- hyaluronic acid interaction. Cell Tissue Res. 281: 317–24.PubMedCrossRefGoogle Scholar
  18. Lokeshwar, V.B., Lokeshwar, B.L., Pham, H.T. and Block, N.L., 1996, Association of elevated levels of hyaluronidase, a matrix-degrading enzyme, with prostate cancer progression. Cancer Res. 56: 651–7.PubMedGoogle Scholar
  19. Madsen, K., Schenholm, M., Jahnke, G. and Tengblad, A., 1989, Hyaluronate binding to intact corneas and cultured endothelial cells. Invest Opth Vis Sci. 30: 2132–7.Google Scholar
  20. Mast, B.A., Haynes, J.H., Krummel, T.M., Diegelman, R.F. and Cohen, IK., 1992, In vivo degradation of fetal wound hyaluronic acid results in increased fibroplasia, collagen deposition, and neovascularization. Plastic. Reconstructive Surgery. 89: 503–9.CrossRefGoogle Scholar
  21. Melder, R.J., Koenig, G.C., Witwer, B.P., Safabakhsh, N., Munn, L.L. and Jain, R.K., 1996, During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumour endothelium. Nature Medicine. 2: 992–997.PubMedCrossRefGoogle Scholar
  22. Montesano, R., Kumar, S., Orci, L. and Pepper, M.S., 1996, Synergistic effect of hyaluronan oligosaccharides and vascular endothelial growth factor on angiogenesis in vitro. Lab Invest. 75: 249–62PubMedGoogle Scholar
  23. Nicosia, R.F., and Ottinetti, A., 1990, Growth of microvessels in serum-free matrix culture of rat aorta. Lab Invest. 63: 115–22.PubMedGoogle Scholar
  24. Noble, P.W., McKee, C.M., Cowman, M. and Shin, H.S., 1996, Hyaluronan fragments activate an NFkB/IkBα autoregulatory loop in murine macrophages. J Exp Med. 186: 2373–2378.CrossRefGoogle Scholar
  25. Noble, P.W., Lake, F.R., Henson, P.M. and Riches, D.W.H., 1993, Hyaluronate activation of CD44 induces insulin-like growth factor-1 expression by tumor necrosis factor-oc-dependent mechanism in murine macrophages. J Clin Invest. 91: 2368–2377.PubMedCrossRefGoogle Scholar
  26. Rooney, P., Wang, M., Kumar, P. and Kumar, S., 1993, Angiogenic oligosaccharides of hyaluronan enhance the production of collagen by endothelial cells. J. Cell Sci. 105: 213–8PubMedGoogle Scholar
  27. Sattar, A., Kumar, S. and West D.C., 1992, Does hyaluronan have a role in endothelial cell proliferation of the synovium. Semin. Arth. Rheum. 21: 43–49.CrossRefGoogle Scholar
  28. Sattar, A., Rooney, P, Kumar, S., Pye, D., West, D.C., Scott, I. and Ledger, P., 1994, Application of angiogenic oligosaccharides of hyaluronan increase blood vessel numbers in rat skin. J. Invest Dermatol. 103: 576–579PubMedCrossRefGoogle Scholar
  29. Shaw, D.M. (1996) Ph.D. Thesis, University of LiverpoolGoogle Scholar
  30. Shaw, D.M., West, D.C. and Hamilton, E., 1994,Hyaluronidase and hyaluronan in tumours and normal tissues, quantity and size distribution. Int J Exp Pathol. 75: A67Google Scholar
  31. Smedrod, B., Pertoft, H., Eriksson, S., Fraser, J.R.E. and Laurent, T., 1984, Studies in vitro on the uptake and degradation of sodium hyaluronate by rat liver endothelial cells. Biochem J. 223: 617–26.Google Scholar
  32. Timar, J., Moczar, E., Timar, F., Pal, K., Kopper, L., Lapis, K. and Jeney, A., 1987, Comparative study on Lewis lung tumor lines with “low” and “high” metastatic capacity. II. Cytochemical and biochemical evidene for differences in glycosaminoglycans. Clin. Expl. Metastasis. 5: 79–87.CrossRefGoogle Scholar
  33. Trouchon, V., Mabilat, C, Bertrand, P., Legrand, Y., Smadia-Joffe, F., Soria, C., Delpeche, B. and Lu, H., 1996, Evidence of involvement of CD44 in endothelial cell proliferation, migration and angiogenesis in vitro. Int. J. Cancer. 66: 664–668CrossRefGoogle Scholar
  34. Watanabe, M., Nakayasu, K. and Okisaka, S., 1993, The effect of hyaluronic acid on proliferation and differentiation of capillary endothelial cells. Nippon Ganka Gakkai Zasshi. 97: 1034–9.PubMedGoogle Scholar
  35. Weidner, N., Semple, J.P., Welch, W.R., and Folkman, J., 1991, Tumour angiogenesis correlates with metastasis in invasive breast carcinoma, N. Engl. J. Med. 324: 1–8.PubMedCrossRefGoogle Scholar
  36. West, D.C., 1993, Hyaluronan receptors on human endothelial cells: the effect of cytokines, in: Vascular Endothelium: Physiological Basis of Clinical Problems II (J.D. Catravas, ed), pp.209–210, Plenumm Press, New YorkCrossRefGoogle Scholar
  37. West, D.C., Hampson, I.N., Arnold, F. and Kumar, S., 1985, Angiogenesis induced by degradation products of hyaluronic acid, Science. 228: 1324–8.PubMedCrossRefGoogle Scholar
  38. West, D.C. and Kumar, S., 1988, Endothelial proliferation and diabetic retinopathy. Lancet. 1: 715–6.PubMedCrossRefGoogle Scholar
  39. West, D.C, and Kumar, S., 1989a, Hyaluronan and angiogenesis, in: The Biology of Hyaluronan, Ciba Foundation Symposium 143 (D. Evered, and J. Whelan, eds), pp. 187–207, John Wiley and Sons, ChichesterGoogle Scholar
  40. West, D.C. and Kumar, S., 1989b, The effect of hyaluronate and its oligosaccharides on endothelial proliferation and monolayer integrity. Exp Cell Res. 183: 179–96.PubMedCrossRefGoogle Scholar
  41. West, D.C. and Kumar, S., 1991, Tumour-associated hyaluronan: a potential regulator of tumour angiogenesis. Int J Radiol. 61/62: 55–60.CrossRefGoogle Scholar
  42. West, D.C, Shaw, D.M., Lorenz, P., Adzick, N.S/ and Longaker M., 1996, Fibrotic healing of adult and late gestation fetal wounds correlates with increased hyaluronidase activity and removal of hyaluronan. Int. J. Biochem Cell Biol. 29: 201–10.CrossRefGoogle Scholar
  43. Yasui, T., Akatsuka, M., Tobetto, K, Umemoto, J., Ando, T., Yamashita, K., and Hayakawa, T., 1992, Effects of hyaluronan on the production of stromelysin and tissue inhibitor of metalloproteinase-1 (TIMP-1) in bovine articular chondrocytes. Biomed Res. 13: 343–8.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • D. C. West
    • 1
  • D. M. Shaw
    • 1
  • M. Joyce
    • 1
  1. 1.Department of Immunology, Faculty of MedicineUniversity of LiverpoolLiverpoolUK

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