Abstract
Growth of vessels under physiological circumstances in adults appears only in female reproductive organs, but can be elicited by endurance training in skeletal and sometimes in cardiac muscle (for review see Hudlicka et al., 1992; Hudlicka and Brown, 1996). However, to achieve an increase in capillary supply of 20% in skeletal muscles takes 5–8 weeks of very intensive endurance training in man (Andersen and Henriksson, 1977), and usually about 12 weeks in animals such as rat (see Gute et al., 1994). Endurance training is obviously linked with a long-term increase in activity of skeletal muscles and hence overload resulting sometimes but not always, in muscle hypertrophy. It also results in an increase in the capacity of the whole vascular bed (Snell et al., 1987) due to high blood flow in contracting muscles.
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References
Adrian, E.D., and Bronk, D.W., 1929, The discharge of impulses in motor nerve fibres, J. Physiol.,Lond. 67:119–151.
Andersen, P., and Henriksson, J., 1977, Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise, J. Physiol., Lond. 270:677–690.
Ando, J., Nomura, H., and Kamiya, A., 1987, The effect of fluid shear stress on the migration and proliferation of cultured endothelial cells, Microvasc. Res. 33:62–70.
Brown, M.D., Cotter, M.A., Hudlicka, O., and Vrbova, G., 1976, The effects of different patterns of muscle activity on capillary density, mechanical properties and structure of slow and fast rabbit muscles, Pflügers Arch. 361:241–250.
Brown, M.D., and Egginton, S., 1988, Capillary density and ultra-structure in rabbit papillary muscle after a high dose of norepinephrine, Microvasc. Res. 36:1–12.
Brown, M.D., and Hudlicka, O., 1991, Capillary supply and cardiac performance in the rabbit after chronic dobutamine treatment, Cardiovasc. Res. 25:909–915.
Brown, M.D., and Hudlicka, O., 1995, Vascular conductance and capillary supply in heart and skeletal muscle in response to altered activity, Microcirculation 2:98.
Brown, M.D., Hudlicka, O., Weiss, J.B., Bate, A., and Silgram, H, 1996, Prazosin-induced capillary growth in rat skeletal muscle; link with endothelial cell-stimulating angiogenic factor, Int. J. Microcirc. 16:207.
Brown, M.D., Davies, M.K., Hudlicka, O., and Townsend, P., 1994, Long-term bradycardia by electrical pacing: a new method for studying heart rate reduction, Cardiovasc. Res. 28:1774–1779.
Burri, P.H., and Tarek, M.R., 1990, A novel mechanism of capillary growth in the rat pulmonary microcirculation, Anat. Rec. 2281:35–45.
Clark, E.R., 1918, Studies on the growth of blood vessels in the tail of the frog, Am. J. Anat. 23:37–38.
Cliff, W.J., 1963, Observations on healing tissues: a combined light and electronmicroscopic investigation, Philos. Trans. R. Soc. Lond. B Biol. Sci. 246:305–325.
Dawson, J.M., and Hudlicka, O., 1989a, The effect of long-term activity on the microvasculature of rat glycolytic skeletal muscle, Int. J. Microcirc. 8:53–69.
Dawson, J.M., and Hudlicka, O., 1989b, The effects of long-term administration of prazosin on the microcirculation in skeletal muscles, Cardiovasc. Res. 23:913–920.
Dawson, J.M., and Hudlicka, O., 1993, Can changes in microcirculation explain capillary growth in skeletal muscle?, Int. J. Exp. Path. 74:65–71.
Denekamp, J., 1984, Vasculature as a target for tumour therapy, Progr. Appl. Microcirc. 4:28–38.
Egginton, S., and Hudlicka, O., 1992, Effect of long-term muscle overload on capillary supply, blood flow and performance in rat fast muscle, J. Physiol, Lond. 452:9P.
Frischknecht, R., and Vrbovâ, G., 1991, Adaptation of rat extensor digitorum longus to overload and increased activity, Pflügers Arch. 419:319–326.
Fulgenzi, G-L., and Hudlicka, O., 1994, The effect of alpha 1 blocker prazosin on capillarization, blood flow and performance in ischaemic skeletal muscles, Int. J. Microcirc. 14:Suppl 1, 37.
Gute, D., Laughlin, M.H., and Amann, F.F., 1994, Regional changes in capillary supply in skeletal muscle of interval-sprint and low-intensity, endurance trained rats, Microcirculation 1:183–193.
Hansen-Smith, F., Egginton, S., and Hudlicka, O., 1997, Growth of arterioles in chronically stimulated adult rat skeletal muscle, Microcirculation5: In press.
Hansen-Smith, F., Egginton, S., Owens, G.K., and Hudlicka, O., 1995, Growth of arterioles in chronically stimulated rat fast muscles, J. Physiol., Lond. 489P:16P.
Hudlicka, O., 1991, What makes blood vessels grow?, J. Physiol, Lond. 444:1–24.
Hudlicka, O., and Brown, M.D., 1991, Capillary growth in normal and hypertrophic heart, in: Cardiac Electrophysiology, Activation, Circulation and Transport.(Review) (S. Sideman, R. Beyar, and A.G. Kleber, eds.), pp. 307–316, Kluwer Academic Publishers, Boston.
Hudlicka, O., and Brown, M.D., 1996, Postnatal growth of the heart and its blood vessels, J. Vasc. Res. 33:266–287.
Hudlicka, O., Brown, M.D., Egginton, S., and Dawson, J.M., 1994, Effect of long-term electrical stimulation on vascular supply and fatigue in chronically ischemic muscles, J. Appl. Physiol. 77:1317–1324.
Hudlicka, O., Brown, M.D., Walter, H., Weiss, J.B., and Bate, A., 1995, Factors involved in capillary growth in the heart, Mol. & Cell. Biochem. 147:57–68.
Hudlicka, O., Brown, M., and Egginton, S., 1992, Angiogenesis in skeletal and cardiac muscle, Physiol. Rev. 72(2):369–417.
Hudlicka, O., and Tyler, K.R., 1984, The effect of long-term high frequency stimulation on capillary density and fibre types in rabbit fast muscle, J. Physiol, Lond. 353:435–445.
Hudlicka, O., Tyler, K.R., Wright, A.J.A., and Ziada, AMAR., 1984, Growth of capillaries in skeletal muscles, Progress in applied microcirculation, 5, pp44–64.
Hudlicka, O., West, D., Kumar, S., El Khelly, F., and Wright, A.J. A., 1989, Can growth of capillaries in the heart and skeletal muscle be explained by the presence of an angiogenic factor? Br. J. Exp. Pathol 70: 237–246.
Jakob, W., Zipper, J., Savoly, S.B., Siems, W.-E., and Jentzsch, KD., 1982, Is dipyridamole an angiogenic agent? Exp. Pathol. 22:217–224.
Mall, G., Mattfeldt, T., Reiger, P., Volk, B., and Frolov, V.A., 1982, Morphometric analysis of the rabbit myocardium after chronic ethanol feeding — early capillary changes, Basic Res. Cardiol. 77:57–67.
Myrhage, R., and Hudlicka, O., 1978, Capillary growth in chronically stimulated adult skeletal muscle as studied by intravital microscopy and histological methods in rabbits and rats, Microvasc. Res. 16:73–90.
Pearce, S., Hudlicka, O., and Egginton, S., 1995, Early stages in activity-induced angiogenesis in rat skeletal muscles: incorporation of bromodeoxyuridine into cells of the interstitium, J. Physiol., Lond. 483:146P.
Price, R.J., and Skalak, T.C., 1996, Chronic alpha-1 adrenergic blockade stimulates terminal and arcade arteriole formation in a network model, Am. J. Physiol. 40:H752–H759.
Romanul, F.C.A., 1965, Capillary supply and metabolism of muscle fibers, Arch. Neurol 12:497–509.
Salmons, S., and Vrbova, G., 1969, The influence of activity on some contractile characteristics of mammalian fast and slow muscles, J. Physiol., Lond. 210:535–549.
Schoefl, G.I., 1963, Studies on inflammation. III. Growing capillaries: their structure and permeability, Virchows Arch. A Pathol. Anat. Histol. 337:97–141.
Sholley, M.M., Ferguson, G.P., Seibel, H.R., Montour, J.L., and Wilson, J.D., 1984, Mechanisms of microvascularization and vascular sprouting can occur without proliferation of endothelial cells, Lab. Invest. 51:624–637.
Snell, P.G., Martin, W.H., Buckey, J.C., and Blomqvist, C.G., 1987, Maximal vascular leg conductance in trained and untrained men, J. Appl. Physiol. 62:606–610.
Tillmans, T.H., Ikeda, S., Hansen, H., Sarma, J.S., Fauvel, J.H., and Bing, R.J., 1974, Microcirculation in the ventricle of the dog and turtle, Circ. Res. 34:561–569.
Tillmans, H., Steinhausen, M., Leinberger, H., Thederan, H., and Kubler, W., 1982, The effect of coronary vasodilators on the microcirculation of the ventricular myocardium, in: Microcirculation of the Heart, (H. Tillmans, W. Kubier, H. Zebes, eds), pp. 305–312, Springer Verlag, Berlin.
Tornling, G., 1982, Capillary neoformation in the heart of dipyridamole treated rats, Acta Pathol. Microbiol. Scand. Sect. A Pathol. 90:269–271.
Tornling, G., Unge, G., Adolfsson, J., Ljungqvist, A., and Carisson, S., 1980, Proliferative activity of capillary wall cells in skeletal muscle in rats during long-term treatment with dipyridamole, Arzneim. Forsch. 30:622–623.
Turek, Z., Kubat, K., Kazda, S., Hoofd, L., and Rakusan, K., 1987, Improved myocardial capillarisation in spontaneously hypertensive rats treated with nifedipine, Cardiovasc. Res. 21:725–729.
Wachtlova, M., Rakusan, K., and Poupa, O., 1965, The coronary terminal vascular bed in the heart of the hare (Lepidns europeus)and the rabbit (Oryctolagns domesticns), Physiol. Bohemoslov. 14:328–331.
Wachtlova, M., Rakusan, K., Roth, Z., and Poupa, O., 1967, The terminal bed of the myocardium in the wild rat (Rattus norvegicus)and the laboratory rat (Rattus norvegicus Lab.), Physiol. Bohemoslov. 16:548–554.
Wright, A.J.A., and Hudlicka, O., 1981, Capillary growth and changes in heart performance induced by chronic bradycardial pacing in the rabbit, Circ. Res. 49:469–478.
Wright, A.J.A., Hudlicka, O., and Brown, M.D., 1989, Beneficial effect of chronic bradycardial pacing on capillary growth and heart performance in volume overload heart hypertrophy, Circ. Res. 64:1205–1212.
Zhou, A.-L., and Egginton, S., 1997, Capillary growth in overloaded rat skeletal muscle: an ultra-structural study, J. Physiol., Lond. 499P:39P.
Zhou, A.-L., Egginton, S., and Hudlicka, O., 1996, Ultrastructural evidence for a novel mechanism of capillary growth in rat skeletal muscle, J. Physiol., Lond. 491:28P.
Ziada, A.M.A.R., Hudlicka, O., Tyler, K.R., and Wright, A.J.A., 1984, The effect of long-term vasodilatation on capillary growth and performance in rabbit heart and skeletal muscle, Cardiovasc. Res. 18:724–732.
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Hudlicka, O., Egginton, S., Brown, M.D. (1998). Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth. In: Maragoudakis, M.E. (eds) Angiogenesis. NATO ASI Series, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9185-3_3
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DOI: https://doi.org/10.1007/978-1-4757-9185-3_3
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