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Angiogenesis pp 203-211 | Cite as

The Interaction of Human Neutrophils with Type IV Collagen Involves an Inhibitory Signal Transduction Pathway

  • Jean Claude Monboisse
  • Georges Bellon
  • Roselyne Garnotel
  • Abdelilah Fawzi
  • Nobuko Ohno
  • Nicholas A. Kefalides
  • Jacques P. Borel
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Type IV collagen is a heterotrimer composed of 3 a chains; these molecules form tetramers by overlap at the amino terminus (7S domain) which further aggregate by end-to-end interaction involving the non-collagenous carboxyl termini (NC1 domains). Collagen is a major component of basement membranes. There are six a chains of type IV collagen whose genes have been cloned. The most predominent heterotrimer is composed of two a-1 and one a-2 chains. It can be prepared by extraction of a mouse sarcoma (EHS tumor) (Wisdom, Gunwar, Hudson, Noelken and Hudson, 1992). Molecular forms of the other type IV collagen chains, a3(IV), a4(IV), a5(IV), a6(IV), have not been isolated (Hudson, Reeders and Tryggwason, 1993; Zhou, Ding, Zhao and Reeders, 1994) and the clones for the a3(IV), a4(IV), a5(IV) and a6(IV) have been reported (Zhou et al., 1994). There is evidence that the latter are also distributed in several types of basement membranes including the kidney glomerulus, the alveolus, the choroid plexus and lens capsule (Ninomiya, Kagawa, Iyama, Naito, Kishiro, Seyer, Sugimoto, Oohashi and Sado, 1995). Lens capsule collagen may be obtained in purified forms. It contains all the types of chains except a6(IV).

Keywords

Phorbol Myristate Acetate Phorbol Myristate Acetate Lens Capsule Basement Membrane Collagen Human Polymorphonuclear Neutrophil 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Jean Claude Monboisse
    • 1
  • Georges Bellon
    • 1
  • Roselyne Garnotel
    • 1
  • Abdelilah Fawzi
    • 1
  • Nobuko Ohno
    • 2
  • Nicholas A. Kefalides
    • 2
  • Jacques P. Borel
    • 1
  1. 1.Laboratory of Biochemistry, CNRS UPRESA 6021University of ReimsReimsFrance
  2. 2.Connective Tissue Research Institute, and Department of MedicineUniversity of Pennsylvania and University City Science CenterPhiladelphiaUSA

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