Lesional Levels of Endothelial Cell Stimulating Angiogenesis Factor (ESAF) and Vascular Endothelial Cell Stimulating Angiogenesis Factor (VEGF) are Elevated in Psoriasis
Psoriasis is a common, disabling, chronic dermatosis that affects approximately 2% of the UK population. Although genetically determined, the usual age of onset of the first lesions is between the ages of 15 and 30. The redness of the psoriatic plaque is dermal hyperaemia which results from dilation and increased tortuosity of capillaries in elongated dermal papillae. Early microvascular changes are amongst the earliest signs of the development of new psoriatic plaques[l]. Thus, psoriasis may be considered as an example of an angiogenic disease.
KeywordsDermal Papilla Psoriatic Skin Vascular Endothelial Cell Growth Factor Chronic Plaque Psoriasis Psoriatic Plaque
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