Structural Studies on Angiogenin, a Protein Implicated in Neovascularization during Tumour Growth
Angiogenesis, the formation of new blood vessels, is an essential part of normal physiological processes such as embryonic growth, wound healing, and the cyclical development of the uterine endometrium. It also occurs in a variety of pathological conditions including arthritis, diabetic retinopathy, and tumour growth (Folkman and Cotran, 1976). Early observers had noted a proliferation of blood vessels in the vicinity of such tumours (see Vallee et al., 1985), and it was later proposed by Folkman (1971) that these tumours are totally dependent on angiogenesis for growth beyond a diameter of 1–2 mm. Angiogenesis is also thought to be a prerequisite for the development of metastases since it provides the means whereby cells disseminate from the original primary tumour.
KeywordsAngiogenic Activity Transition State Analog Stereo View Massachusetts 02115 Ribonucleolytic Activity
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