Thymosin Beta 4 Promotes Endothelial Cell Migration and Angiogenesis
The basement membrane associated with endothelial cells is important in regulating the passage of macromolecules and cells in and out of the circulation, forming a barrier to the underlying stroma and maintaining the differentiated phenotype of the endothelial cells (Grant et al., 1990). During the formation of new blood vessels, the basement membrane is first degraded and then the endothelial cells migrate away from the vessel, proliferate at the site of migration initiation and subsequently a new basement membrane is synthesized when the vessel is formed. Normally the vasculature is fairly stable with minimal turnover. During tissue formation, in wound repair and in certain diseases, considerable increases in vessel formation occur (Folkman, 1992). Using in vitro and in vivo assays, a number of factors have been described that regulate this process. Many of these factors are either stored in the basement membrane or produced by cells in response to the basement membrane.
KeywordsMigration Estrogen Polypeptide Interferon Macromolecule
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