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Angiogenesis pp 121-128 | Cite as

Angiogenic Mediators in Wound Healing

  • Luisa A. DiPietro
  • Nicholas N. Nissen
Chapter
Part of the NATO ASI Series book series (NSSA, volume 298)

Abstract

Angiogenesis is an essential component of normal wound repair. Neovascularization provides nutrient support to healing tissue, promotes granulation tissue formation, and assists in the clearance of debris. Despite the prominent role of angiogenesis in the repair process, the primary mediators of wound angiogenesis have been difficult to define. An abundance of potential angiogenic agonists and antagonists have been identified in healing wounds (Table I), suggesting that the net angiogenic stimulus relies upon a balance of positive and negative mediators. The identification of this rather plentiful number of candidate mediators seems to indicate that angiogenesis in wounds is regulated by a most redundant and complex mechanism.

Keywords

Vascular Endothelial Growth Factor Basic Fibroblast Growth Factor Angiogenic Activity Vascular Endothelial Cell Growth Factor Wound Fluid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Luisa A. DiPietro
    • 1
  • Nicholas N. Nissen
    • 1
  1. 1.Burn and Shock Trauma Institute, Department of Surgery, LoyolaUniversity Medical CenterMaywoodUSA

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