Angiogenic Mediators in Wound Healing
Angiogenesis is an essential component of normal wound repair. Neovascularization provides nutrient support to healing tissue, promotes granulation tissue formation, and assists in the clearance of debris. Despite the prominent role of angiogenesis in the repair process, the primary mediators of wound angiogenesis have been difficult to define. An abundance of potential angiogenic agonists and antagonists have been identified in healing wounds (Table I), suggesting that the net angiogenic stimulus relies upon a balance of positive and negative mediators. The identification of this rather plentiful number of candidate mediators seems to indicate that angiogenesis in wounds is regulated by a most redundant and complex mechanism.
KeywordsVascular Endothelial Growth Factor Basic Fibroblast Growth Factor Angiogenic Activity Vascular Endothelial Cell Growth Factor Wound Fluid
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- Antoniades, H.N., Galanopoulos, T., Neville-Golden, J., Kiritsy, C.P., and Lynch, S.P., 1994, Expression of growth factor and receptor mRNAs in skin epithelial cells following acute cutaneous injury, Am. J. Pathol. 142:1099–1110.Google Scholar
- Ferrara, N., Houck, K., Jakeman, L., and Leung, D., 1992, Molecular and biological properties of the vascular endothelial growth factor family of proteins, Endocrine Rev. 13:18–32.Google Scholar
- Gupta, V.K., McNeil, P.L., Riegner, C., and Howdieshell, T.R., 1996, Vascular endothelial growth factor is a key mediator of omental angiogenesis, Surg. Forum 47:746–749.Google Scholar