Angiogenesis — Critical Assessment of in-Vitro Assays and in — Vivo Models

  • David BenEzra
Part of the NATO ASI Series book series (NSSA, volume 298)


Angiogenesis or neovascularization is a complex in-vivo phenomenon. Originally postulated more than 50 years ago by Michaelson, the growth of new blood vessels (either from stem cells during embryogenesis or from pre-existing mature vessels during wound healing processes) is most probably stimulated by released chemical factors1. Michaelson alluded to the existence of an x-factor of neovascularization and studied its expression in experimental models and clinical conditions1,2. Attempts to isolate the Michaelson x-factor have led to the discovery of a myriad of “angiogenic factors”3–6.


Vascular Endothelial Cell Angiogenic Factor Wound Healing Process Mitogenic Activity Corneal Angiogenesis 


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    Aharonov O., Maftzir, G. and BenEzra, D: The role of cytokines in angiogenesis Ocular Immunology and Inflammation 1:135–141, 1993.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • David BenEzra
    • 1
  1. 1.Dept. of OphthalmologyHadassah University HospitalJerusalemIsrael

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