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Detection of Antineutrophil Cytoplasmatic Antibodies (ANCA) and their Association with other Autoantibodies in Patients with Hepatobiliary Disorders

  • Rudi Gruber
  • Carsten Brockmeyer
  • Wilma Hoechtlen-Vollmar
  • Renate Bittlingmaier
  • Susanne Trimborn
  • Gert Riethmüller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Sera from 35 out of 655 patients with suspected or confirmed hepatobiliary diseases were positive for anti-neutrophil antibodies with a perinuclear staining pattern (p-ANCA). Nineteen of these sera did not react with myeloperoxidase (MPO), Cathepsin G or Elastase, the three proposed antigens of p-ANCAs. No distinct antigen for these sera could be characterized by western blot techniques with fractionated granulocyte proteins.

Keywords

Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Chronic Active Hepatitis Hepatobiliary Disease Western Blot Technique 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Rudi Gruber
    • 1
  • Carsten Brockmeyer
    • 1
  • Wilma Hoechtlen-Vollmar
    • 1
  • Renate Bittlingmaier
    • 1
  • Susanne Trimborn
    • 1
  • Gert Riethmüller
    • 1
  1. 1.Institute for ImmunologyUniversity of MunichGermany

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