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Antineutrophil Antibodies in Inlammatory Bowel Disease Recognize Different Antigens

  • A. H. Leontine Mulder
  • Jan Broekroelofs
  • Gerda Horst
  • Piet C. Limburg
  • G. Frits Nelis
  • Cees G. M. Kallenberg
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

Anti-neutrophil cytoplasmic antibodies (ANCA) were observed in 31 out of 68 sera (45%) from Ulcerative Colitis (UC) patients and in 13 out of 38 Crohn’s Disease (CD) sera (34%). The presence of ANCA was not related to disease activity, nor to the localization of the disease manifestations. By Western Blotting ANCA showed reactivity with either lactoferrin, polypeptides occurring as a doublet of 66/67 kD MW, or polypeptides occurring as a doublet of 63/54 kD MW.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Primary Sclerosing Cholangitis Sclerosing Cholangitis Disease Manifestation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • A. H. Leontine Mulder
    • 1
  • Jan Broekroelofs
    • 2
  • Gerda Horst
    • 1
  • Piet C. Limburg
    • 1
  • G. Frits Nelis
    • 2
  • Cees G. M. Kallenberg
    • 1
  1. 1.Dept. of Clinical ImmunologyUniversity Hospital GroningenGroningenThe Netherlands
  2. 2.Dept. of Internal MedicineSophia HospitalZwolleThe Netherlands

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