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Anti-Neutrophil Cytoplasmic Auto-Antibodies (ANCA) in Patients with Ulcerative Colitis (UC): Influence of Disease Activity and Familial Study

  • Dominique Reumaux
  • Jean-Frédéric Colombel
  • Laurence Delecourt
  • Laure-Hélène Noël
  • Antoine Cortot
  • Patrick Duthilleul
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 336)

Summary

In ours series 1) no relationship between ulcerative colitis (UC) activity and antineutrophil cytoplasmic auto-antibodies (ANCA) monitored by indirect immunofluorescence was observed in sera from 25 repeatedly tested patients with UC 2) ANCA did not appear as being potentially a genetic marker of susceptibility to UC as previously reported.

Keywords

Inflammatory Bowel Disease Ulcerative Colitis Indirect Immunofluorescence Allergy Clin Immunol Healthy Blood Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Saxon, A., Shanahan, F., Landers, C., Ganz, T., Targan, S., 1990, A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease, J Allergy Clin Immunol. 86: 202–10PubMedCrossRefGoogle Scholar
  2. 2.
    Duerr, R.H., Targan, S., Landers, C.J., Sutherland, R., Shanahan, F., 1991, Neutrophil autoantibodies in ulcerative colitis: comparison with other colitides/diarrheal diseases, Gastroenterology 100: 1590–6PubMedGoogle Scholar
  3. 3.
    Colombel, J.F., Reumaux, D., Duthilleul, P., Noel, L.H., Gower-Rousseau, C., Paris, J.C., Cortot, A., 1992, Antineutrophil cytoplasmic auto-antibodies in inflammatory bowel disease, Gastroenterol Clin Biol. 16: 656–660PubMedGoogle Scholar
  4. 4.
    Rump, J.A., Schölmerich, J., Gross, V., Roth, M., Helfesrieder, R., Rautmann, A., Lüdemann, J., Gross, W.L., Peter, H.H., 1990, A new type of perinuclear anti-neutrophil cytoplasmic antibody (p-ANCA) in active ulcerative colitis but not in Crohn’s disease, Immunobiol 181: 406–13CrossRefGoogle Scholar
  5. 5.
    Roth, M., Gross, V., Andus, T., Rump, J.A., Peter, H.H., Schölmerich, J., 1991, Influence of disease activity and therapy on p-ANCA reactivity of sera from repeatedly tested patients with ulcerative colitis (UC), Eur J Gastroenterol Hepatol 3 (Suppl 1): 250AGoogle Scholar
  6. 6.
    Shanahan, F., Duerr, R., Rotter, J., Yang, H., Sutherland, L., McElree, C., Landers, C., Targan, S., 1991, Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity, Gastroenterology 100: 614 A.Google Scholar
  7. 7.
    Calkins, B.M., Lillienfeld, A.M., Garland, C.F., Mendeloff, A.I., 1984, Trends in incidence rates of ulcerative colitis and Crohn’s disease, Dig DisSci. 29: 913–20Google Scholar
  8. 8.
    Truelove, S.C., Witts, L.J., 1955, Cortisone in ulcerative colitis. Final report on atherapeutic trial, BrJ Med. 2: 1041–8CrossRefGoogle Scholar
  9. 9.
    Wiik, A., 1989, Delineation of a standard procedure for indirect immunofluorescence detection of ANCA, APMIS97 (Suppl 1 ): 12–13Google Scholar
  10. 10.
    Shanahan, F., Landers, C., Duerr, R., Targan, S.R., 1991, Neutrophil autoantibodies as disease markers for ulcerative colitis, Immunol Res. 10: 479–484PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Dominique Reumaux
    • 1
  • Jean-Frédéric Colombel
    • 2
  • Laurence Delecourt
    • 2
  • Laure-Hélène Noël
    • 3
  • Antoine Cortot
    • 2
  • Patrick Duthilleul
    • 1
  1. 1.Service d’Hématologie-ImmunologieCentre HospitalierValenciennes CédexFrance
  2. 2.Service des Maladies de l’Appareil Digestif et de la NutritionCHRU LilleFrance
  3. 3.Inserm U90Hôpital NeckerParisFrance

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